Male Genital Tract Immunology

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Male Genital Tract Immunology

The male reproductive tract is the primary site for the maintenance of male reproduction and hormone secretion, as well as the entry point of sexually transmitted pathogens. On the one hand, the immune regulation of the male genital tract maintains normal spermatogenesis while on the other hand, the local microenvironment of the immune system plays a key role in preventing the invasion by pathogenic microorganisms.

Infection and inflammation of the male genital tract are thought to be the primary etiological factors of male infertility. Prevalence rates for male infertility attributable to infection range from 6% to 15% in reports from andrology outpatient clinics. Despite that inflammation of the male genital tract is correlated with infections, there are still other events or diseases that impair germ cells including testis cancer, trauma, toxic agents, cryptorchidism and systemic autoimmune diseases. The constant release of highly immunogenic antigens from the damaged seminiferous epithelium or from mature spermatozoa may damage the immune tolerance to spermatic antigens and induce autoimmune orchitis, sterile epididymitis, or autoimmune prostatitis. Therefore, unraveling the molecular microenvironment of the male genital tract is of great interest to understand the immunopathological mechanisms of male infertility and to design novel effective therapeutics for male reproductive health.

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Media Contact:
Stella M
Journal Manager
Immunome Research
Email: immunores@longdom.org