Jumping genes also provide genomic stability

Image The DNA molecule inside the nucleus of any human cell is more than six feet long. To fit into such a small space, it must fold into precise loops that also govern how genes are turned on or off. It might seem counterintuitive that bits of DNA that randomly move about the genome can provide stability to these folding patterns. Indeed, the discovery contradicts a long-held assumption that the precise order of letters in the DNA sequence always dictates the broader structure of the DNA molecule. In places where the larger 3D folding of the genome is the same between... Read More

Applications of Microbiology

Image Applications of Microbiology While some fear microbes due to the association of some microbes with various human diseases, many microbes are also responsible for numerous beneficial processes such as industrial fermentation (e.g. the production of alcohol, vinegar and dairy products), antibiotic production and act as molecular vehicles to transfer DNA to complex organisms such as plants and animals. Scientists have also exploited their knowledge of microbes to produce biotechnologically important enzymes such as Taq polymerase, reporter genes for use in other genetic systems and novel molecular biology techniques such as the yeast two-hybrid system.[citation needed] Bacteria can be used for... Read More

Birth of Applied Microbiology

Image Birth of Applied Microbiology Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue (volume 6 issue 1 ) in the form of Research, Reviews, Commentaries, Letter to Editor, Case Reports, Short Communication, Images, Conference... Read More

Genetic Syndrome and Gene Therapy New Arena

Image Genetic Syndrome and Gene Therapy New Arena Visakhapatnam, 29-11-2019 The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy. The genetic information lies within the cell nucleus of each living cell in the body. The information can be considered to be retained in a book... Read More

Gene Expression New arena

Image Gene Expression New arena Visakhapatnam, 29-11-2019 Journal of Genetic Syndromes & Gene Therapy enhancing the academic communication between scholars and seeking professionals to join as an editorial board Member (or) reviewer team. The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. Journal of Genetic Syndromes & Gene Therapy (JGSGT) brings... Read More

Identification of Novel MicroRNAs and their Target Prediction in Stevia rebaudiana

Image miRNAs are a class of endogenous, small, noncoding, ~22 nucleotides single-stranded RNAs that act as posttranscriptional regulators in eukaryotes . They have reported to be located mostly within noncoding regions of genomes, and usually transcribed from RNA polymerase II promoters . The generation of mature miRNA is a complicated enzyme-catalyzed process, from the initial transcript pri-miRNA to the precursor (pre-miRNA) with a characteristic hairpin structure, then a miRNA duplex (miRNA:miRNA* ). In the end, the mature miRNAs function within large complexes to negatively regulate specific target mRNAs. Perfect complementarity between miRNA: mRNA strand generally results in cleavage,... Read More

A breakthrough for a rare genetic disorder

Image Duchenne Muscular Dystrophy (DMD) is a rare genetic disorder that has affected 0.8 million male children in India. DMD occurs due to deficiency in the manufacture of dystrophin — a protein located primarily in skeletal muscles — used during movement, besides in other organs such as lung, heart and in the brain’s nerve cells. This affects their functioning. The symptoms include muscle degeneration and weakness, which goes on to affect various physiological activities of the patient including breathing and blood circulation. The disease usually affects male children between the ages of three and 15. The patient is... Read More

Oesophageal Perforation Management in A Tertiary Care Hospital

Image Recognition of oesophageal injury is often delayed due to its protean manifestations. Principles of management are: control of sepsis and contamination by diversion and/ or drainage, nutrition, broad spectrum antibiotics and restoration of continuity. Age, general condition of the patient, aetiology, the anatomical location and size of perforation, early versus delayed presentation, clinical condition of the patient, underlying oesophageal disease and other associated co-morbid medical conditions are important determinants of the outcome. Primary repair is the gold standard treatment in early hours. Drainage and diversion are required when perforation is not localised and in late and unstable cases. Endoscopic stenting... Read More

Clinicopathological profile of primary mediastinal masses-Our experience

Image The mediastinum starts from thoracic inlet superiorly and up to the diaphragm inferiorly, bounded laterally by both the pleura. It’s further divided into anterior, middle and posterior mediastinum to categorize the tumor and diseases of mediastinum according to their site and location. A variety of tumor and cysts occur in the mediastinum and affect people of all ages. Primary mediastinal tumors are rare representing 3% of all tumors within the chest with an average incidence of 8 cases seen per year2-4. Neoplastic masses can be both benign and malignant in nature and can be primary or secondary in origin. The... Read More

Definition of Potential Targets in Mycoplasma pneumoniae

Image Whole genome sequencing technology provided expensive information for the identifi cation of new therapeutic targets in pathogens over and above human genome. Subtractive genomic approach is extremely informative technique to identify the potential targets, which are expected to be essential genes or proteins in pathogen but absent in host, which can be used as drug target. Besides it uncharacterized proteins, which are present on the exposed surface of pathogen, may also be consider as drug target. In present study subtractive genomic approach has been used to identify therapeutic target in Mycoplasma pneumoniae, which is atypical pneumonia causing pathogen in human.... Read More

Probiotics for Celiac Disease

Image Celiac Disease (CD) or gluten sensitive enteropathy is anautoimmune disorder characterised by variable presentations which respond to exclusion of wheat and other gluten containing products. While exclusion of gluten is the corner stone in the management ofthis entity, newer therapeutic approaches are now being investigated. These include use of elemental diets, oral prolyl-endopeptidases, IL-15blockage, transamidation of wheat and use of probiotics. The microbial composition of the gut of patients with active CD isdifferent from healthy controls. In a report assessing the duodenal microbiota in CD it was noted that the ratio of Lactobacillus-Bifidobacterium to... Read More

Off Label Antiviral Therapeutics for Henipaviruses

Image A study on the prevalence of common intestinal parasitic diseases with a high carriage rate within the global population in Senegal was conducted among HIV-infected persons. A systematic parasitological stool test from 150 patients HIV infected showed a low carriage rate10.6% (16/150). The following parasites were isolated: Entamoeba coli 4% (6/150), Ascaris lumbricoides 2.6% (4/150) and Trichuris trichiura 1.3% (2/150). The 31-50 age group was the most affected one. The carriage rate stood at 93.3% among patients with a CD4 T-cell rate <500/ mm3, without any significant difference compared to intestinal parasite negative patients. In tropical areas, one of the... Read More

The association of HLA-A, -B gene polymorphisms with acute lymphoblastic leukemia (ALL) in Iranian patients

Image Leukemia was the first disease in which the involvement of the major histocompatibility complex (MHC) was reported. MHC is a polygenic and polymorphic system containing the loci for genes coding class I, II and III of HLA (Human Leukocyte Antigen) genes which are one of the most polymorphic loci in the human genome, located on the short arm of chromosome 6 (6p23). In the present study, the relation between HLA-A,-B various alleles and ALL disease was investigated in Iranian patients. Eleven ALL cases who referred to bone marrow transplantation department of Taleghani Hospital and fifty healthy controls were randomly selected.... Read More

Abortion

Image Abortion is the ending of a pregnancy by removal or expulsion of an embryo or fetus before it can survive outside the uterus. An abortion that occurs without intervention is known as a miscarriage or spontaneous abortion. When deliberate steps are taken to end a pregnancy, it is called an induced abortion, or less frequently "induced miscarriage". The unmodified word abortion generally refers to an induced abortion. A similar procedure after the fetus has potential to survive outside the womb is known as a "late termination of pregnancy" or less accurately as a "late term abortion". Types: Induced: An induced... Read More

Gene therapy

Image Gene therapy (also called human gene transfer) is a medical field which focuses on the utilization of the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease. The first attempt at modifying human DNA was performed in 1980 by Martin Cline, but the first successful nuclear gene transfer in humans, approved by the National Institutes of Health, was performed in May 1989. Cell types: Somatic: In somatic cell gene therapy (SCGT), the therapeutic genes are transferred into any cell other than a gamete, germ cell, gametocyte, or undifferentiated stem cell. Any such modifications affect... Read More

Mini-Tablet Drug Delivery System

Image    Drug Designing: Open Access mainly focus on designing new drugs, research and developments, clinical experiments, drug delivery systems, and adverse events, biochemistry and pharmacological aspects.Drug Design and Drug Discovery Hit to Lead and its treatment and many other interesting research topics in the field of Drug Design and Discovery. The journal also involves the inventive process of finding new medications based on the knowledge of a biological target. The Development of Pediatric Dosage Forms  is challenging and it’s mainly due to the differences in swallowing abilities, taste preferences, and dosage requirements of children. The most commonly prescribed dosage form... Read More

Rational Drug Design for New Kinase Inhibitors

Image  Drug Designing: Open Access (ISSN 2169-0138) presents up-to-date coverage of advanced drug systems and their applications in medicine. Moreover, it brings the latest advances in fast-moving areas such as new drug approvals, covering all aspects of theory, research and application of diverse disciplines about Medicinal Chemistry Research and drug discovery and design. In the most basic sense, drug design involves the design of molecules that are complementary in shape and charge to the biomolecular target with which they interact and therefore will bind to it. Drug design frequently but not necessarily relies on computer modeling techniques.Rational drug design refers to the development of medications based on the study of... Read More

Latest methodlogy and Innovations in swarm intelligence

Image Swarm intelligence is the discipline that deals with the study of self-organizing processes both in nature and in artificial systems. Researchers in ethology and animal behaviour have proposed a number of models to explain interesting aspects of collective behaviours such as movement coordination, shape-formation or decision making. Recently, algorithms and methods inspired by these models have been proposed to solve difficult problems in many domains. Among these, it is worth mentioning ant colony optimization (ACO) and particle swarm optimization (PSO), focusing respectively on discrete and continuous optimisation problems.... Read More

Exploring the Benefits and Advancements in Swarm Intelligence

Image Machine Learning and Computational Intelligence There is an increasing need for the application of Machine Learning (ML) and Computational Intelligence (CI) techniques, which can effectively perform image processing operations (such as segmentation, co-registration, classification, and dimensionality reduction), in the fields of neuroimaging and oncological imaging. Although the manual approach often remains the golden standard in some tasks (e.g., segmentation), ML can be exploited to automate and facilitate the work of researchers and clinicians. Frequently used techniques include Support Vector Machines (SVMs) for classification problems, graph-based methods, and Artificial Neural Networks (ANNs).... Read More

Innovation and Development in the field of Ophthalmology

Image Ophthalmology deals with the diagnosis and treatment of eye disorders, especially in children. This also refers to the procedures right from the diagnosis till the treatment and even till the postoperative care. It indicates the functions of the medical practitioner in an eye clinic and includes an extended form of research from pivotal screening diagnosis to the treatment to treat eye disorders. Myopia Hyperopia Visual Acuity Ophthalmic Oncology A Black eye can occur when we got an injury bruising around the eye or... Read More

Exploring the recent advancements in Optometry

Image "Ophthalmic Surgery” gathering will focus on most recent and energizing developments in zones of eye medical procedures, diagnostics and late advances towards eye mind. Since the eventual fate of ophthalmology lies in research, information and innovation and its quick interpretation into the center to encourage patients 2019" is the latest slanting development in numerous fields especially in wanders like remedial, restorative fields, affiliations, associations et cetera. The present time totally taken off with various new computerization developments . In such case recuperating focuses and distinctive organizations are exceptionally benefitted by the use of ... Read More

Cell Structure of Human cell recently discovered

Image Author Name: Keith Howell Category Name: Genetics and molecular Biology Description: Cell Structure of Human cell recently discovered  The structure is a new type of protein complex that the cell uses to attach to its surroundings and proves to play a key part in cell division.The cells in a tissue are surrounded by a net-like structure called the extracellular matrix. To attach itself to the matrix the cells have receptor molecules on their surfaces, which control the assembly of large protein complexes inside them. These so-called adhesion complexes connect the outside to the cell interior and also signal to the... Read More

Death from cancer among intellectually disabled persons in Japan

Image Death from cancer among intellectually disabled persons in Japan BACKGROUND: It is important to know the causes of death of intellectually disabled (ID) persons, but there have been few reports about them in Japan. MATERIALS AND METHODS: The numbers of deaths due to the diseases of the large classification of the ICD10 (Chapters 1-14) in 2005 in 5-year age categories were obtained from the vital statistics of Japan (excluding Chapters 15-22; i.e., external causes, etc.). The numbers of persons in 2005 in 5-year age categories were obtained from the census of Japan. Based on these data, the general mortality rates of the... Read More

Methods of inducing breast cancer in animal models: a systematic review

Image Methods of inducing breast cancer in animal models: a systematic review Abstract Objective: Breast cancer is the second leading cause of death and the most common cancer in women. With respect to a large number of limitations in human studies, there is the need to develop experimental animal models. The purpose of this study was to investigate the development of breast cancer in laboratory animals.   Materials and Methods: This systematic review was conducted based on the PRISMA checklist. Articles were extracted with selected keywords from the PubMed, SID, Springer, Medlib and SinceDirect databases without any language restrictions. 450 articles... Read More

Types of Immunotherapies

Image Immunotherapy is the treatment of disease by activating or suppressing the immune system. Immunotherapies designed to elicit or amplify an immune response are classified as activation immunotherapies, while immunotherapies that reduce or suppress are classified as suppression immunotherapies.   In recent years, immunotherapy has become of great interest to researchers, clinicians and pharmaceutical companies, particularly in its promise to treat various forms of cancer.   Immunomodulators:  Immunomodulators are the active agents of immunotherapy. They are a diverse array of recombinant, synthetic, and natural preparations.   Activation immunotherapies:   Cancer:  Cancer treatment used to be focused on killing or removing cancer... Read More

Immuno-Oncology | Cancer research

Image Cancer immunotherapy (sometimes called immuno-oncology) is the artificial stimulation of the immune system to treat cancer, improving on the immune system's natural ability to fight the disease. It is an application of the fundamental research of cancer immunology and a growing subspeciality of oncology. It exploits the fact that cancer cells often have tumor antigens, molecules on their surface that can be detected by the antibody proteins of the immune system, binding to them. The tumor antigens are often proteins or other macromolecules (e.g. carbohydrates). Normal antibodies bind to external pathogens, but the modified immunotherapy antibodies bind to the tumor... Read More

Immunoinformatics Approach-Multiple Peptides Vaccine Design from Glycoprotein E of Herpes Simplex Virus-3

Image Immunoinformatics Approach-Multiple Peptides Vaccine Design from Glycoprotein E of Herpes Simplex Virus-3 Background: Herpes simplex virus (HSV) is a common human pathogen, causing infections of orofacial mucosal surfaces (HSV-1) and genital mucosal surfaces (HSV-2). Productive infection results in the formation of vesicular lesions in the mucosal epithelia, followed by spread of the virus to sensory neurons and establishment of a latent infection that may remain for the life of the host. Material and method: All sequences of glycoprotein E [Human herpes virus 3] were obtained from NCBI and these sequences were subjected to IEDB predicted tools, including B cell and... Read More

Applications of Microfluidics & Lab-on-a-chip

Image Lab-on-a-chip (LOC) devices integrate and scale down laboratory functions and processes to a miniaturized chip format. Many LOC devices are used in a wide array of biomedical and other analytical applications including rapid pathogen detection, clinical diagnosis, forensic science, electrophoresis, flow cytometry, blood chemistry analysis, protein and DNA analysis. LOC devices can be fabricated from many types of material including various polymers, glass, or silicon, or combinations of these materials. Chemical synthesis, Drug Discovery & Development Biomarkers, Circulating Tumor Cells & Single Cell Analysis Biofabrication, Bioprinting & Disease Modelling ... Read More

Adapting the Future Technologies to break free from Design Limitations

Image Advances in 3D Printing: Trend setting innovations for 3D printing and additive manufacturing and how these advances have changed the essence of immediate, computerized advances for fast creation of models, models and examples. In light of its wide applications, 3D printing and additive manufacturing technology has become an amazing new modern upset in the field of assembling. The advancement of 3D printing and additive fabricating advances has changed plan, building and assembling forms crosswise over enterprises, for example, purchaser items, aerospace, medicinal gadgets and automotives. Impact of 3D printing: The... Read More

Androgen Receptor as Prognostic Marker in Triple-Negative Breast Cancer Patients

Image Androgen Receptor as Prognostic Marker in Triple-Negative Breast Cancer Patients Purpose: The purpose of this study was to assess the prognostic impact of androgen receptor (AR) expression in patients with triple-negative breast cancer (TNBC). Methods/patients: 101 patients treated for primary TNBC without distant metastasis from 1999 to 2015 were identified from breast surgery database. Kaplan-Meier and Cox regression models evaluated disease-free survival (DFS) and overall survival (OS). Results: AR expression was positive (IHC>1%) in 40% of patients. OS at 36 and 60 months was 86% and 80% in AR-negative patients, and 100% and 96% in AR-positive patients (log rank test... Read More

Ocular Biomechanics

Image Traditionally, biomechanical properties of the cornea have been assessed in vitro by measuring stress-strain and Young modulus on corneal strips. In 2005, the Ocular Response Analyzer(ORA) was launched as the first commercial device claiming to provide in vivo measurements of corneal biomechanics. It utilizes a dynamic bi-directional applanation process in which two applanation pressure measurements are recorded: one while the cornea is moving inward, and the other as the cornea returns. The primary output measurements are Goldmann correlated intraocular pressure (IOPg), and a new parameter called corneal hysteresis (CH), defined by Reichert as the... Read More

Age-related Macular Degeneration

Image Age-related Macular Degeneration (AMD or ARMD) also called macular degeneration is deterioration of the macula, which is the small central area of the retina of the eye that controls visual acuity. The health of the macula determines our ability to read, recognize faces, drive, watch television, use a computer or phone, and perform any other visual task that requires us to see fine detail. Macular degeneration is classified as either dry AMD or wet AMD. Dry AMD: Dry macular degeneration is an early stage of the disease. It appears to be... Read More

Proteomics Is Ready for Primetime

Image Over the past two decades, medicine has been moving towards data-driven diagnoses and personalized therapies based on molecular information.1 Oncology is a prime example, with an ever-growing range of precision drugs designed to target specific driver mutations in cancer cells. However, while these drugs have provided some benefits, they have failed to transform survival in most tumor types. Frustratingly, identification of a particular genetic alteration is not enough to guarantee that a treatment will work. For example, drugs targeting the overactive V600E form of the signaling protein BRAF are effective in melanoma but have no activity in colorectal... Read More

Diagnosing rare diseases using RNA: A Q&A

Image Every person distills down to a script of DNA, and researchers are increasingly mining this genetic information to better inform care. Now, scientists have shown how RNA -- an offshoot of DNA -- is coming into its own as doctors sleuth out difficult-to-diagnose illnesses. In a new study in Nature Medicine, Stephen Montgomery, PhD, a Stanford associate professor of pathology and of genetics, shows why the transcriptome, the collection of RNA molecules in a cell, is a crucial clue to help decipher the source of some rare diseases. I had a chance to chat with Montgomery, getting his take on the value of transcriptomics,... Read More

Gene Mutations

Image Gene Mutations   Mutations are changes in the genetic sequence, and they are a main cause of diversity among organisms. These changes occur at many different levels, and they can have widely differing consequences. In biological systems that are capable of reproduction, we must first focus on whether they are heritable; specifically, some mutations affect only the individual that carries them, while others affect all of the carrier organism's offspring, and further descendants. For mutations to affect an organism's descendants, they must: 1) occur in cells that produce the next generation, and 2) affect the hereditary material. Ultimately, the interplay... Read More

Journal of Genetic Syndromes & Gene Therapy

Image Journal of Genetic Syndromes & Gene Therapy Journal of Genetic Syndromes & Gene Therapy is an open access publisher which provides scientific information to all the researchers and academicians in all quarters. This Genetics journal is using Editorial Manager System for online manuscript submission, review and tracking. Editorial board members of the Genetic Syndromes & Gene Therapy or outside experts review manuscripts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable https://www.longdom.org/genetic-syndromes-gene-therapy.html  Mutations are changes in the genetic sequence, and they are a... Read More

HBV Vaccine Used

Image Infection with hepatitis B virus (HBV) can be prevented by vaccination with HB surface antigen, which induces HBS specific antibodies and T cells. But the immunization status of workers and its relationship with occupational factors are not well documented. The goal is to examine the factors of risk and the immunization status against HBV among a population of workers. An assessment of the vaccination and the immunization status against HBV was conducted among a miscellaneous population of French workers, recruited from a medical occupational center, during a cross-sectional study. A representative sample of a population of 3000 workers enrolled, was... Read More

Congenital Rubella with Autism

Image The conventional diagnosis of congenital rubella is a rare occurrence of an obvious maternal exposure, resulting in an infant born with obvious signs such as cataracts, deafness, microcephaly or congenital heart disease. In this case, a mother with no known symptom, sign or exposure of rubella gave birth to a male infant without complication. The infant had no notable abnormalities at birth. The boy had developmentally delayed, and between the ages of five and seven years was diagnosed with autism. At the age of ten years, an MRI of his brain evidenced a remote stroke. Careful examination of all medical... Read More

Medical Microbiology : A Guide to Microbial Infections

Image                Medical Microbiology : A Guide to Microbial Infections Applied Microbiology: Open Access is a scholarly open access journal that deals with the study of Medical microbiology the study of the pathogenic microbes and the role of microbes in human illness, Pharmaceutical microbiology the study of microorganisms that are related to the production of antibiotics, enzymes, vitamins and vaccines, Industrial microbiology the exploitation of microbes for use in industrial processes It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue (volume... Read More

Latest update of Applied Microbiology

Image Latest update of Applied Microbiology LATEST RESEARCH NEWS ON SACCHAROMYCES CEREVISIAE Transcriptional Regulatory Networks in Saccharomyces cerevisiae We have determined how most of the transcriptional regulators encoded within the eukaryote Saccharomyces cerevisiaeassociate with genes across the genome in living cells. even as maps of metabolic networks describe the potential pathways which will be employed by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to manage global organic phenomenon programs. We use this information to spot network motifs, the only units of specification, and demonstrate that an automatic process can use... Read More

Probiotic Potential in Fermented Food

Image Probiotics have been defined a number of times. Presently the most common definition is that from the FAO/WHO which states that probiotics are “live microorganisms that, administered in adequate amounts, confer a health benefit on the host.” One of the most significant groups of probiotic organisms are the lactic acid bacteria, commonly used in fermented dairy products. There is an increase in interest in these species as research is beginning to reveal the many possible health benefits associated with lactic acid bacteria. The difficulty in identifying and classifying strains has complicated research, since benefits... Read More

Research in Plant Biochemistry & Physiology

Image Journal of Plant Biochemistry & Physiology is mostly focusing on releasing articles related to Plant Biosystems, Plant Ecology, Plant production science, Plant signaling & behavior, virology, mycology, bacteriology,  nematology, plant neurobiology. The open access journal is published by Longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. We are privileged to welcome researchers to our journal. Right from 7 years we have been working in publishing quality articles which improved citations world wide of our journal irrespective of the type of the article. This achievement... Read More

Bioethics and Food Restrictions by Religious Motivations: Decision Making Processes in Health

Image Bioethics reflects about much health related issues. Spiritual aspects involved in decision making are one of them. The inclusion of spiritual aspects in the Bioethics arena does not remove the secular character of bioethical reflection. In contrast, considering spiritual aspects may gave a broad and more complex understanding about motivations associated with the decisions that people make the Clinical Bioethics Committee of the Hospital de Clínicas de Porto Alegre, since 1993, had the mission to assist health professionals, patients and families in bioethical issues associated with the decision making process. Individual food choices can be conditioned by a great variety... Read More

Determinants of Emergency Hospital Admissions among Patients in Blackpool, England: Population-Based Cross-Sectional Study

Image   Introduction: Emergency hospital admissions have been increasing in the UK over recent years [1,2]. With the predicted increase of about 53% in the proportion of people aged 65 and over in the UK between 2001 and 2013 [3] this trend is set to continue as some evidence suggest that the ageing population structure will be associated with increases in the number and frequency of emergency admissions [4]. In addition to its impact on health service resources, hospitalisation can lead to adverse consequences particularly for older people, including breakdown of formal and informal care, loss of social networks, and premature... Read More

Epidemiology and Etiology of Renal calculi

Image Drug Designing: Open Access, is an peer-reviewed, open-access scholarly journal focused on publishing articles in all aspects of academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. Renal calculi are crystalline structures of calcium oxalate with associated risk factors like dehydration, high fat diet, animal protein, high salt intake and obesity.... Read More

Bacteriophages for Detection and Control Pathogens

Image Bacteriophages are viruses infecting bacteria; they are obligate intracellular parasites also require their own metabolism. Phages are excessively host-specific, capable only to infect certain classifications or even strains. Following their detection beginning in the 20th century, phages were expansively applied to treat diverse bacterial disorders in people and animals. At present, as the problem of antibiotic resistance serves ever more severe, several scientists also clinicians are observing again at bacteriophages as a therapeutic choice in the treatment of bacterial infections. The aim of this review is to consider the current evidence on the effects of bacteriophages for detection and control... Read More

Drug Discovery

Image The drug industry is one of the major players guiding the development of the medicines, biotechnology & pharmacology field. Drug discovery is the process by which drugs are discovered and designed. It is a process which aims at identifying a compound therapeutically useful in curing & treating disease. The process of drug discovery involves the identification of candidates, synthesis, characterization, screening & assays for therapeutic efficacy. Once a compound has shown its value in these tests, it will begin the process of drug development prior to clinical trials. Developing a new drug is a tedious & expensive undertaking, despite promising... Read More

Computational Approach Towards Designing Potential HIV Inhibitors

Image It is imperative to continue efforts to identify novel effective therapies that can assist in containing the spread of HIV. Recently acquired knowledge about the HIV entry process points to new strategies to block viral entry. For most HIV strains, the successful infection of their target cells is mainly dependent on the presence of the CD4 surface molecule, which serves as the primary virus receptor. The attachment of the viral envelope to this cellular CD4 receptor can be considered as an ideal target with multiple windows of opportunity for therapeutic intervention. Therefore, drugs that interfere with the CD4 receptor, and... Read More

Social Science Rules!

Image Sociology is the field of sciences worried about the investigations of the public activity of human gatherings and people. Social examinations is a term used to portray the expansive investigation of different fields which includes past and current human conduct and connections. Research &Review: Journal of Social Science on revelation and development in different angles like Sociology, Geography, Economics, History, Cultural examinations, Ethnography, Sociolinguistics, Home science, Demography, Political sciences and so forth Surveys, Mini Reviews, Short Communications, Perspectives/Opinions, Letters, Short Note and Commentaries are acknowledged for production. This is an open access diary where one can discover logical research as... Read More

Teratogenic Effects – Leadings to Neonatal Disorders

Image Teratogen:  A teratogen is an agent that can disturb the development of the embryo or foetus Teratogenicity: It refers to the capacity of a drug to cause foetal abnormalities when administered to the pregnant mother. Drugs can affect the foetus at 3 stages: Fertilization and implantation: conception to 17 days—failure of pregnancy which often goes unnoticed. Organogenesis: 18 to 55 days of gestation, most vulnerable period, deformities are produced. Growth and development: 56 days onwards —developmental and functional abnormalities can occur Some Drugs and Its Teratogenic effects: Thalidomide: Thalidomide is widely used drug in 1950 and... Read More

Virology & Mycology – Deadly combination

Image Virology is the investigation of infections, nucleic corrosive edifices, and proteins equipped for replication in cells of people, plants, and microorganisms. Infections usurp the jobs of the host cells wherein they are parasites to imitate themselves. Mycology is the organic branch worried about the investigation of growths, including their hereditary and biochemical properties, scientific categorization and human use as a wellspring of tinder, prescription (e.g., penicillin, yeast disease medication), nourishment (e.g., lager, wine, cheddar, consumable mushrooms) and entheogenes, just as their perils, for example, harming or contamination. Virology and Mycology includes all parts of creature (or) plant... Read More

SHOULD EVERY WEEK BE INFECTION CONTORWEEK?

Image Journal of Infectious Diseases & Preventive remedy is an open access, peer reviewed journal that publishes data on clinical, preventative, healing and social factors of Transmittable diseases. Journal of Infectious Diseases & Preventive medication focus on discovery and innovation in more than a few aspects of Infectious Disease Eradication, Neglected Diseases, Nosocomial Infection, Threshold Host Density, Microbiome Project, Pandemics, Mycology, Airborne Disease etc. Reviews, Mini Reviews, Short Communications, Case Reports, Perspectives/Opinions, Letters, Short Note and Commentaries are usual for publication. The Journal is correctly walking in the 7th Volume which covers a huge variety The Journal emphasizes high-level lookup and... Read More

Investigating the Mucosal Immnue system Activity

Image Mucosal insusceptibility is the investigation of the invulnerable framework related with mucosal locales, for example, the gut mucosa that involves Peyer's patches (PPs), intestinal lamina propria, intestinal intraepithelium, cryptopatches, secluded lymphoid follicles in the gut antimesenteric divider, and the mesenteric lymph hubs. Mucosal layer is the sodden, internal most covering of organs and body pits, for example, the nose, mouth, lungs, and stomach. Mucosal organs emit bodily fluid which is a thick, elusive liquid. This mucosal layer secretes constantly secretes bodily fluid which empowers grease of nourishment particles, likewise at whatever point any antigen enters our body enacts our... Read More

Unknown Secrets behind Aging

Image Maturing is the on-going period of our lives not just for individuals likewise for living life forms. A few of us are intrigued to be sound and youthful during 70's and 80's of our life and even researchers working in this field are distinguishing exceptional courses in making new Anti-maturing creams, hostile to wrinkle creams, things important to maintain a strategic distance from to stay away from age related infections (making them to change the way of life) and to improve the psychological abilities. Journal of Aging Science is generally focussing on discharging articles identified with age related maladies,... Read More

Contemporary exploration in the field of Dermatology

Image Dermatology centers around the analysis and treatment of conditions identified with skin, hair and nails. It additionally focuses on keeping up the wellbeing of your skin. Your skin is your body's biggest organ, which covers and secures your body. Anything that aggravates stops up or arouses your skin can cause side effects, for example, redness, growing, consuming and tingling. As of now in time, the whole world is experiencing skin related ailments like psoriasis, skin inflammation, dermatitis, rashes, skin inflammation, dandruff, skin contaminations, skin consumes, rosacea, Vitiligo, moles, skin labels and so on. As an outcome we need to offer... Read More

Eradicating the infections caused by the microorganisms

Image The microorganisms impact the endurance of each animal on the planet. Not every one of them causes sicknesses but rather larger part is totally innocuous. As Bacteria and Parasite are an extent of Microbiology, they are additionally the explanation behind existing diseases on the planet. On a very basic level, we need to understand that Disease is the point at which the contamination makes harm the person's essential capacities or frameworks. A contamination doesn't generally bring about sickness! They cause reactions as well as these moment living things are fundamental to the cycling of supplements in the eco-frameworks of the... Read More

Antioxidant Activity of Polyphenolic Flavonoid of herbals

Image   Objective: Phytochemical constituents of herbal extracts has shown positive response of antioxidant activity. The purpose of the present study was to investigate the antioxidant activity of polyphenolic flavonoids in the ethanolic extract of stem of Nicotiana tabacum. Materials and Methods: Flavonoids contents were determined by both thin layer chromatography and aluminium chloride colorimetric method, where as phenolic content was determine by Folin-Ciocalteau method. Antioxidant activity was observed by determining the electron transfer (DPPH free radical scavenging), enzymatic biochemical assay (SOD and GST activity) and nonenzymatic biochemical assay (GSH content and lipid peroxidation). Results: Flavonoid and phenolic content were found... Read More

MicroRNAs in the Cholinergic Anti-Inflammatory Pathway: Immunotherapy

Image Immunotherapy: Open Access was congratulating its authors of most cited articles. The article entitled “MicroRNAs in the Cholinergic Anti-Inflammatory Pathway: ProspectiveTherapeutic Targets for Inflammatory Diseases” which was written by Yang Sun and Xia Liu was mostly cited article which was published in 2016 from Department of Pharmacology, Second Military Medical University School of Pharmacy, Shanghai, China by Yang Sun and Xia Liu.   It is the editorial published by the editor Xia Liu who was one of the eminent editorial board members of Immunotherapy: Open Access.   The article will be... Read More

Cancer research and Immuno-Oncology

Image Cancer immunotherapy is a therapy used to treat cancer patients that involves or uses components of the immune system. Some cancer immunotherapies consist of antibodies that bind to, and inhibit the function of, proteins expressed by cancer cells. Other cancer immunotherapies include vaccines and T cell infusions.   Cancer research ranges from epidemiology, molecular bioscience to the performance of clinical trials to evaluate and compare applications of the various cancer treatments. These applications include surgery, radiation therapy, chemotherapy, hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the emphasis in clinical cancer research shifted towards... Read More

Lyme Disease

Image Lyme Disease Lyme disease is the most common vector-borne disease in the United States. Lyme disease is caused by the bacterium Borrelia burgdorferi and rarely, Borrelia mayonii. It is transmitted to humans through the bite of infected blacklegged ticks. Typical symptoms include fever, headache, fatigue, and a characteristic skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. Lyme disease is diagnosed based on symptoms, physical findings (e.g., rash), and the possibility of exposure to infected ticks.  Laboratory testing is helpful if used correctly and performed with validated methods. Most cases... Read More

Comparative and Evolutionary Studies of the Lysosomal 2-Sulfoglucuronate Sulfatase

Image Arylsulfatase K (ARSK) is one of 17 sulfatase gene family members encoded on the human genome for which a role has been recently identified as a lysosomal 2-sulfoglucuronate sulfatase. Vertebrate ARSK sequences shared 60-82%identity but only <27% identities with other arylsulfatase family members. Comparative enzyme structures were studied,including residues with predicted roles in forming N-glycosylation sites, Ca2+ binding and active site residues. VertebrateARSK genes usually contained 8 coding exons. A human ARSK gene promoter comprised CpG61 and multiple TFBS,which may be involved in signal transduction, transcription activation or regulating entry into cell division. Phylogeneticanalyses examined evolutionary changes... Read More

Meningioma with Remarkable Multiple Rosette Formation: A Diagnostically Difficult Case

Image Meningioma with Remarkable Multiple Rosette Formation: A Diagnostically Difficult Case Lipomas are the most common soft tissue tumors that are encountered in clinical practice; however, the giant lipomas are extremely uncommon and are entities of great concern as they can often create a diagnostic dilemma and therapeutic challenge owing to their size, location and their close relationship with other benign and malignant mesenchymal neoplasms. These tumors are rarer in children as compared to the adults, with very few cases reported in the surgical literature worldwide. We herein present a case of a giant lipoma of the right shoulder in an... Read More

Lentinan Exerts its Anti-Inflammatory Activity by Suppressing TNFR1 Transfer to the Surface of Intestinal Epithelial Cells through Dectin-1 in an in vitro and mice model

Image Lentinan Exerts its Anti-Inflammatory Activity by Suppressing TNFR1 Transfer to the Surface of Intestinal Epithelial Cells through Dectin-1 in an in vitro and mice model It has been reported that lentinan, β-1,3; 1,6-glucan derived from Lentinula edodes, suppresses intestinal inflammation and ameliorates symptoms of colitis. However, the mechanism of intestinal anti-inflammatory activity of lentinan and how it is recognized by intestinal epithelial cells remains largely unclear. The receptor for lentinan on intestinal epithelial cells was identified using an in vitro gut inflammation model consisting of Caco-2 and RAW264.7 cells. Colitis was induced in 7 to 8 week-old wild-type (WT) or... Read More

Tuberculosis

Image Tuberculosis Tuberculosis -- or TB, as it’s commonly called- is a contagious infection that usually attacks your lungs. It can spread to other parts of your body, like your brain and spine. A type of bacteria called Mycobacterium tuberculosis causes it. There are two forms of the disease: Latent TB: You have the germs in your body, but your immune system stops them from spreading. That means you don’t have any symptoms and you’re not contagious. But the infection is still alive in your body and can one day become active. If you’re at high risk for re-activation -- for... Read More

Food Borne Illness

Image Food Borne Illness Foodborne illness (also foodborne disease and colloquially referred to as food poisoning) is any illness resulting from the spoilage of contaminated food, pathogenic bacteria, viruses, or parasites that contaminate food, as well as toxins such as poisonous mushrooms and various species of beans that have not been boiled for at least 10 minutes. Symptoms vary depending on the cause, and are described below in this article. A few broad generalizations can be made. For contaminants requiring an incubation period, symptoms may not manifest for hours to days, depending on the cause and on quantity of consumption. Longer... Read More

Bidirectional Regulation of A beta Aggregates: Immunotherapy

Image Immunotherapy: Open Access has published an article entitled “Bidirectional Regulation of A beta Aggregates: Focus on TherapeuticTargets for Alzheimer's Disease” in its volume 3 Issue 3 written by Ying Zhang, and Jiang-Tao Li.   The article explains about Bidirectional Regulation of A beta Aggregates: Focus on TherapeuticTargets for Alzheimer's Disease.   Commentary was as follows regarding Alzheimer disease (AD) is the most prevalent dementia of agingadult, characterized by progressive amyloid aggregates in the brain andimpairment  in  cognition  and  memory.  In  recent  year,  data  fromclinical trials and mouse models showed that Aβ immunotherapy hadbrought new hopes to AD treatment, although undesirable... Read More

Current trends in Cancer Research and Immuno-Oncology

Image Journal of Cancer Research and Immuno-Oncology is one of the most promising and rapidly developing areas of cancer research. The journal focuses on the development of new therapies which improve human body’s immune response against cancer.Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in the area of cancer biology, tumor and stem cell biology, immunology, microenvironment and immunology, molecular and cellular pathobiology, immuno-oncology, prevention and epidemiology, therapeutics and targets.   Journal of Cancer Research and Immuno-Oncology is focused on publishing articles on various areas of immunotherapy like cancer immunotherapy, tumor... Read More

Advanced Surgeries

Image Oral and Maxillofacial Surgery is a specialist branch of dentistry which specialize in disorders of the mouth, teeth, jaws and facial structures. It encompasses diagnosis, surgical and related management of various conditions such as impacted/embedded teeth misaligned jaws, facial pain and trauma, snoring/obstructive sleep apnea and oral cancer. Major complex surgery in OMFS is exciting, and often collaborative. It includes: craniofacial surgery for congenital problems, cancer and injuries involving the skull base, facial surgery for cancer, skin cancer surgery. Certain list of procedures undertaken by oral and maxillofacial surgeons include: surgical treatment of facial injuries, removal of head and neck... Read More

About Journal of Cancer Research and Immuno-Oncology

Image Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc   This Journal provides a unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on any array of latest cancer research and Immuno-Oncology. The Journal of Cancer... Read More

A new RNA sequencing approach: what is single cell transcriptomics?

Image Single cell transcriptomics is a next-generation RNA sequencing approach which allows a high-resolution view of cells. Researchers from University of Southern Denmark, Wellcome Sanger Institute and BGI, published the study in the journal Genome Biology. What is single cell transcriptomics? RNA sequencing uses next-generation sequencing to analyse the presence of RNA in a sample.1,2 According to the University of Southern Denmark, single cell transcriptomics (i.e. scRNA-seq) is a next-generation sequencing approach that simultaneously measures the messenger RNA concentrations (encoded by DNA/genome/genetic blueprint) of thousands of genes, in individual cells. This new approach allows a high-resolution view of... Read More

About Immunotherapy: Open Access

Image Immunology is a branch of biomedical science which deals with an organism’s response towards an invading environmental factor. This process involves a complex interplay of invading particle and defence system of the host organism along with successive cascading molecular mechanism to eliminate the invading agent.   Immunotherpay: Open Access is using Editorial Tracking System for quality in review process. Editorial Tracking is an online manuscript submission, review and tracking systems used by most of the best open access journals. Review processing is performed by the editorial board members of Immunotherpay: Open Access or outside experts; at least two independent reviewers... Read More

Genes and Ontogenes in Drosophila: The Role of RNA Forms

Image The goals of genetics are to explore and establish the link between a trait and a heredity factor. In turn, the central dogma of molecular biology posits the flow of genetic information from DNA through RNA to protein, which ultimately forms a trait. In this currently accepted scenario, the genetic system is formed by universal genes that function to produce proteins. Nonetheless, multiple lines of evidence indicate that this is not the sole scenario of how genetic systems may operate. Let us begin with logics. Modern genetics is based on the classic postulates that (i) any living... Read More

Food Microbiology – main part to learn to be healthy

Image Food Microbiology – main part to learn to be healthy Applied Microbiology: Open Access is a scholarly open access journal that deals with the study of Medical microbiology the study of the pathogenic microbes and the role of microbes in human illness, Pharmaceutical microbiology the study of microorganisms that are related to the production of antibiotics, enzymes, vitamins and vaccines, Industrial microbiology the exploitation of microbes for use in industrial processes It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue... Read More

Inviting for Articles : Applied Microbiology

Image Inviting for Articles : Applied Microbiology Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the form of Research, Reviews, Commentaries, Letter to Editor, Case Reports, Short Communication, Images, Conference Proceedings which will  be published in... Read More

Journal of Surgery and Anesthesia Invites Manuscripts for Volume 4, Issue 1

Image Journal of Surgery and Anesthesia is a peer reviewed, open access journal dedicated to publishing research on all aspects of surgery and anaesthesia. This journal aims to keep anaesthesiologists, anaesthetic practitioners, surgeons and surgical researchers up to date by publishing clinical & evidence based research. It would be our extreme pleasure to invite you to submit your manuscripts to our journal for our upcoming issue Volume 4, Issue 1. We would appreciate receiving your submission on or before January 25th, 2020 OR let us know your feasible time to extend the deadline. Your submissions... Read More

Genetic syndromes-New 2020 Issue

Image Genetic syndromes-New 2020 Issue Journal of Genetic Syndromes & Gene Therapy is an open access publisher which provides scientific information to all the researchers and academicians in all quarters. Journal of Genetic Syndromes & Gene Therapy (JGSGT) brings articles in all areas related to Genetics such as Genetic disorders, Genetic mutations, Auto immune diseases etc on Quaterly basis. JGSGT welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately 7 days after acceptance. https://www.longdom.org/genetic-syndromes-gene-therapy.html Relevant fields: 1.single-gene disorders include cystic fibrosis, alpha- and beta-thalassemias,... Read More

Gene Mapping

Image Gene Mapping NLM ID: 101574143 Index Copernicus Value 2016: 84.15 The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy. Genetic Syndromes & Gene Therapy is an official peer-reviewed journal for the rapid publication of innovative research covering all aspects of Gene Mapping and Gene... Read More

Pneumococcal Vaccination

Image In 2014 the Advisory Committee on Immunization Practices (ACIP) approved a dose of 13-valent pneumococcal conjugate vaccine (PCV13) for all adults at age 65 years. This further complicated the pneumococcal vaccination schedule, which was already one of the most complicated schedules. This study documents simplified schedules that were considered and discarded by the pneumococcal working group before making the most recent recommendation. We examined the marginal cost-effectiveness of several simplified schedules for older adults (age 50+ years) when compared with current recommendations. Our primary outcome was the cost-effectiveness ratio of quality-adjusted life years to cost. We used a probabilistic model... Read More

Emergence of Antibiotic Resistance

Image The capacity of bacteria to resist against the ejects of an antibiotic is called antibiotic resistance. Antibiotic resistance is due to the change in bacteria by some approach that eliminates or reduces the efficiency of chemicals, drugs, or other agents designed for treatment against infections. The survival and continuously multiplication of bacteria causes more destruction in human body. A few years back, main focus of research was centered regarding gram-positive bacteria resistant. Currently, clinical microbiologists strongly are in view that multidrug-resistant gram-negative bacteria are the major risk for human health. The gram-negative bacteria resistance increasing faster than in gram-positive bacteria.... Read More

Diverse Diagnosis of a Single Sinonasal Mass and how was Mystery Solved

Image Diverse Diagnosis of a Single Sinonasal Mass and how was Mystery Solved Abstract Background: Although the nasal cavity and paranasal sinuses occupy a relatively small anatomical space, they are the site of origin of some of the more complex, histologically diverse group of tumours in the entire human body. Carcinomas of the nasal cavity and paranasal sinuses account for 0.2-0.8% of all malignant neoplasms and 3% of those occurring in the head and neck. Sinonasal undifferentiated carcinoma is a very rare tumour with fewer than 100 reported cases. Case report: In our case, a 50yr female came to the... Read More

Multifocal Angiosarcoma of the Scalp: Review of the Literature and Report of Two Cases

Image Multifocal Angiosarcoma of the Scalp: Review of the Literature and Report of Two Cases Abstract Cutaneous angiosarcoma of the head and neck is a rare disease with a very difficult treatment. We report two cases of patients with cutaneous angiosarcoma of the scalp and a review of the literature. Both patients were female and their average age was 70.3 years. In the two cases, the clinical presentation of the angiosarcoma was a multifocal tumor of the scalp with bleeding and ulceration. One of the patients had regional lymph node metastasis and the other had lung metastasis. Both lesions received... Read More

Latest technology Methods in Artificial Intelligence & Swarm intelligence

Image AI & Swarm intelligence is the latest trending technology in many fields especially in industries like Manufacturing, Automation, Control Systems, Healthcare, Energy, Transport, Defence, Space, Data Mining, etc. Artificial Intelligence will be a common platform to gain knowledge and share new ideas amongst the Technologist, Professionals, Industrialists, Researchers, Innovators and students from research area of Machine Learning. Experts will share their research experiences and engage in many interactive discussions at the event. Our high-level conferences will bring together forward thinking brands, market leaders, AI & Swarm intelligence evangelists... Read More

Innovative Studies on Artificial Intelligence

Image The Artificial Intelligence is intended to present within a single forum all of the developments in the field of multi-sensor, multi-source, multi-process information fusion and thereby promote the synergism among the many disciplines that are contributing to its growth. Abstracts are invited on the various topics like Data/Image, Feature, Decision, and Multilevel Fusion, Multi-classifier/Decision Systems, Multi-Look Temporal Fusion, Multi-Sensor, Multi-Source Fusion System Architectures Distributed and Wireless Sensor Networks. Neural systems Artificial Intelligence covers information processing in natural and artificial neural systems. The conference presents a fresh, unidiomatic attitude towards this multi-disciplinary... Read More

Visualizing the Latest Advancements in Ophthalmology

Image Ophthalmology is a stream of medicine dealing with eye and visual system. Ophthalmology completely relates to both internal visual system and external parts such eye ball, eye lid, eye lashes and tear formation. Treatments include right from external eye care to using medical, surgical and rehabilitate methods to treat various eye related problems. Many specialists such as Ophthalmologists, Optometrists, Vision Specialists working on various aspects to eradicate blindness. To have blind free world, it is very important for the clinicians and researchers to meet and discuss about the various aspects to... Read More

Exploring the Perspective in the Field of Ophthalmology

Image Our aim is to provide the surgeons, refractive surgeons, optometrists, opticians, young researchers, students, industrial delegates and anyone professionally involved in study of Ophthalmology and Eye care and surgery with an opportunity to learn about the complexity of the disease, discuss interventional procedures, look at new and advanced cataract removal practices and their efficiency and efficacy in the treatment of various refractive errors and cataract extraction, and understand local realities and practical constraints in improving vision-care. Ophthalmology Ophthalmology is that the specialty involved with the medical and... Read More

Instructions for Authors for submitting Manuscript to Cancer Research and Immuno-Oncology

Image Journal of Cancer Research and Immuno-Oncology brings articles in all areas related to cancer immunotherapy, immunotherapy, tumor immunology, necrosis, nucleic acid research, immune suppression, immunosurveillance, tumor immunity,  immunotherapies, metastatic cancer, immune system, chemotherapy, etc.   Journal of Cancer Research and Immuno-Oncology is a fast-developing open access journal in the field of cancer research. It focuses on becoming one of the best peer reviewed journal in the field of cancer research. Journal of Cancer Research and Immuno-Oncology covers a broad scope for the authors to make their valuable contributions in cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc... Read More

Multiplex Immunohistochemistry: The Importance of Staining Order

Image Immunotherapy: Open Access has recently published an article entitled “Multiplex Immunohistochemistry: The Importance of Staining Order WhenProducing a Validated Protocol” in its volume 5 Issue 2 written by Jihad Syed, Jack Ashton, Jesuchristopher Joseph, Gemma N Jones, Christian Slater, Alan Sharpe,Garry Ashton, William Howat, Richard Byers, Helen K Angell from Institute  of  Cancer  Sciences,  University  of  Manchester,  Manchester,  UK and Translational  Medicine,  Oncology  R&D,  AstraZeneca, Cambridge, UK.   The article explains about the complexity of multifactorial diseases, such as cancer, poses significant challenges to the development of personalised therapies. Integrated digital histological analysis of tumoursprovides a better understanding of the... Read More

Journal of Clinical Research and Bioethics (Volume 11; Issue 1)

Image Journal of Clinical Research and Bioethics is committed to disseminate research output to the scientific community without any hassle. Articles published under OMICS Banner are freely available throughout the world, ensuring the author′s presence through his/her contribution worldwide. Since OMICS International is under the terms of Creative Commons Attribution License, it enables the redistribution and re-use of the original work, as we deposit them in reputed indexing databases on behalf of author. Open Access Through Open Access publication, authors benefit in number of ways: • Standards of high-quality, rapid peer-review and production ... Read More

Journal of Clinical Research and Bioethics have Exclusive Offer “Free Annual Publication with One Time Membership Fee.”

Image Journal of Clinical Research and Bioethics(ISSN: 2155-9627) has announced Annual Membership with exclusive discount on article processing charge to commemorate on its Anniversary. The Journal Journal of Clinical Research and Bioethics is an Open access academic journal that encompasses a wide range of current research on General ethics,  Animal ethics, Health Care, Human Experimentation, Death and dying, ethics in relation to abortion, bioethics and philosophy of science, public ethics, ethics in disaster medicine  and other related fields and offers a promising platform for the authors to make their valuable contributions towards the journal. The Editorial Board of Journal of Clinical Research... Read More

Anatomy of Iranian species Teucrium polium

Image Teucrium (Lamiaceae) is a large and polymorphic genus distributed mainly in the Europe, North Africa and in the temperate parts of Asia. In Iran, 12 species are native. In this study, the anatomical features of the leaf and stem Teucrium polium are investigated. T. polium belonging to sect. Polium is a perennial herb growing on Lorestan province. The anatomical studies on T. polium revealed that the stem shares the general characteristics of the Labiatae family. The leaves clearly exhibit xeromorphy due to features such as the thick cuticle layer, thick outer epidermal cell wall, a high density of trichomes and... Read More

Seed coat morphology of the genus Juncus L.

Image The seed morphology of six species of the genus Juncus L. (Juncaceae), involving wild annuals and perennials was studied in Northeast of Iran using Light and Scanning Electron Microscope (SEM). Seed morphology (light microscope) of the investigated species exhibits certain variations in shape, size and surface ornamentation. Results of SEM analysis reveals that there are different patterns of seed surface. Seed shape and surface structure exhibit some diversity among taxa indicating systematic significance in species differentiation. An identification key to the investigated taxa is provided based on seed characters in this research. he genus Juncus L. (Juncaceae) is a widely... Read More

Antiviral Activity of Emetine Dihydrochloride

Image Dengue fever has become a global concern as dengue infections are prevalent in the tropics and the subtropics, and can lead to a severe life-threatening illness. Currently, there is a widespread interest to search for vaccine or antiviral therapy to combat DENV infection. In this study, we have identified emetine dihydrochloride with potent antiviral activity against DENV infection. Emetine was also shown to inhibit DENV replication consistently in all the dengue serotypes. Experiments were designed to define the stage of viral replication cycle at which emetine blocked DENV infection. Emetine did not target the entry process of DENV into cells... Read More

Cardiovascular Manifestation of HIV

Image HIV infection is a leading health problem across the entire world, including United States. Recent advances in medicine have led to a significant decline in mortality associated with HIV infection and hence increased life expectancy in HIV-infected individuals. Cardiovascular complications represent an increasingly important health concern in HIV-infected population especially after the introduction of anti-retroviral therapy. Numerous research studies have demonstrated the increased prevalence of cardiovascular disease in HIV infected individuals. The etiology of the preponderance of cardiovascular manifestations associated with HIV is still not well established. It may be attributed to virus itself, the effects of anti-retroviral medications; or... Read More

Computer Aided Drug Designing

Image Drug Designing: Open Access is an scientific, peer reviewed journal that covers research original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. Computational approaches are useful tools to interpret and guide experiments to expedite the antibiotic drug design process. Structure based drug design (SBDD) and ligand based drug design (LBDD) are the two general types of computer-aided drug design (CADD) approaches in existence. To know more about the article: https://www.longdom.org/drug-designing/archive.html           Manuscripts can be published through the ... Read More

Co-expression of PD-L1 Antibodies Enhances the Anti-Tumor Efficacy

Image Chimeric antigen receptor T cell (CAR-T) therapy has shownsignificant efficacy in treating patients with refractory B-cellleukemia and lymphoma [1,2]. However, CAR-T therapy hasyielded less favorable results in treating patients with solidtumors such as pancreatic, ovarian or mesothelioma cancers[3-5]. One of the major obstacles in treating solid tumors withCAR-T is the scarcity of antigen that is uniformly expressed intumor cells such as CD19 in B cell hematologic malignancies[6,7]. Therefore, designing a CAR against an antigen that ishighly expressed in cancer cells but either has negligible orreduced expression in normal tissues to avoid off-tumor toxicityis extremely critical. Several CAR-T clinical trials in... Read More

Immunotherapy: Open access | Call for papers

Image Journal of Immunotherapy: Open access features rapid publication of articles on immunomodulators, lymphokines, antibodies, cells, and cell products in cancer biology and therapy. Laboratory and preclinical studies, as well as investigative clinical reports, are presented. The journal emphasizes basic mechanisms and methods for the rapid transfer of technology from the laboratory to the clinic. IMT contains full-length articles, review articles, and short communications.   Instructions for authors are as follows:   Manuscript important element properties   Title: Title should be clear, meaningful and brief (no longer than 25 words). The abbreviations should not be used in the title. ... Read More

Developing Electronic-nose Technologies for Clinical Practice

Image Developing Electronic-nose Technologies for Clinical Practice The development of relatively simple gas-sensing devices with sensor arrays capable of constructing molecular profiles of complex Volatile Organic Compound (VOC) metabolites from clinical samples, based on production of healthy or disease-specific digital signature patterns, may soon help to revolutionize diagnostic procedures in clinical practice. This mini-review summarizes the development of recent portable electronic-nose (e-nose) technologies as new diagnostic tools with the potential for accelerating clinical procedures to facilitate non-invasive early disease diagnoses, improving the speed and ac To know more about the article: https://www.longdom.org/medical-surgical-pathology/current-issue.html How we work: After submission, an acknowledgement with manuscript... Read More

Issues and Perspectives in Psoriasis Management

Image Issues and Perspectives in Psoriasis Management Psoriasis is recognized as a chronic inflammatory autoimmune disease caused by genetics, the immune system and environmental factors with inherent aberrations in the skin in the form of either consistently excess proliferation of cellular constituents, particularly the epidermis, keratinocytes to hyperproliferate and perpetuate the disease process. Psoriasis varies in severity from small, localized patches to complete body coverage. These skin patches are typically red, dry, itchy and scaly. Humans lose five thousand million skin cells every day. How this colossal shedding process can occur without there being a break in the skin barrier is... Read More

Latest Breakthrough in Cell signaling

Image Journal of Cell Signaling brings articles in all areas related to effector systems, such as protein kinases, lipid signaling pathways, cyclic nucleotide signaling processes, NO signaling and ion channels. The production, regulation, degradation and action of second messengers; the structure, regulation, degradation and action of receptors; Guanine nucleotide regulatory proteins; Bio-informatics studies related to cell signaling mechanisms.  A new area for bioscience and clinical researchers to explore. In humans, signalling in cells normally regulates cell growth and repair. However, abnormal cell signalling contributes to many diseases, including cancer and neurodegeneration. Therefore, identifying specific proteins that control cell... Read More

Modern Approaches in Drug Designing & Drug Designing

Image Drug Designing: Open Access is a peer-reviewed multidisciplinary scholarly journal aims to publish reliable source of scientific information on Drug Research and applied fields. The Journal aims to provide platform for the researchers, expertise in physics sciences disciplines, for disseminating experimental and theoretical reports reporting the progress of Physics Research and its advancing significant interdisciplinary applications  Latest research in all related fields of drug targets, rational drug discovery, computer-aided drug design and the different types of drug design, development methods. Patient safety, clinical outcomes, programs for the development, safety and sustained use of medicines will be an... Read More

Plant It & It will give you Life

Image Journal of Plant Biochemistry & Physiology is celebrating 7th Anniversary it’s been seven years we have started the Journal. The open access journal is published by Longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. We are privileged to welcome researchers to our journal. The Journal of Plant Biochemistry & Physiology aims to broadcast the latest findings from systematic explorations in the areas of Plant Biochemistry, Herbs Plants, Plant Medicine, Aromatic Plants, and Fragrant Plants; Healing Herbs; Aromatic Flowers, Common Plants, Aromatic Crops, History... Read More

Developmental Learning Perspective of Swarm Intelligence Algorithms

Image Swarm intelligence algorithm is confirmed by briefly considering brain evolution, brain development, brainstorming process, etc. Several swarm intelligence algorithms are looked at from developmental learning perspective. Finally, a framework of a developmental swarm intelligence algorithm is given to help understand developmental swarm intelligence algorithms, and to guide to design and/or implement any new developmental swarm intelligence algorithm and/or any developmental evolutionary algorithm. Swarm intelligence algorithm develops its learning capacity that can better solve an optimization problem which is unknown at the algorithm’s design or implementation time.  In the... Read More

Human Comprehension of Fairness in Machine Learning

Image AI & Swarm intelligence is the latest trending technology in many fields especially in industries like Manufacturing, Automation, Control Systems, Healthcare, Energy, Transport, Defence, Space, Data Mining, etc. Artificial Intelligence will be a common platform to gain knowledge and share new ideas amongst the Technologist, Professionals, Industrialists, Researchers, Innovators and students from research area of Machine Learning. Experts will share their research experiences and engage in many interactive discussions at the event. Bias in machine learning has manifested injustice in several areas, such as medicine, hiring, and criminal... Read More

Latest Methology and process in Ophthalmology Exploring the Novel Research in Eye

Image The retina, which begins from the parallel midbrain, creates through the development of the optic vesicle and the consequent development of the optic glass with its unpredictable two-walled structure with retinal colour epithelium on the external divider and the neural retina on the inward divider. A predominant hypothesis is that signs and associations with encompassing tissues, for example, the focal point, instigate the arrangement of the optic container. Others have proposed that this procedure is a cell-self-sufficient process and can act naturally started and shaped without outward acceptance. The major microorganisms... Read More

Innovations in Ophthalmology for the Treatment of Eye Disorders

Image Our aim is to provide the surgeons, refractive surgeons, optometrists, opticians, young researchers, students, industrial delegates and anyone professionally involved in study of Ophthalmology and Eye care and surgery with an opportunity to learn about the complexity of the disease, discuss interventional procedures, look at new and advanced cataract removal practices and their efficiency and efficacy in the treatment of various refractive errors and cataract extraction, and understand local realities and practical constraints in improving vision-care  Ophthalmology Ophthalmology is that the specialty involved with the medical and surgical... Read More

Bioinformatics Market Growing Technology Trends and Business Opportunities by 2025

Image Bioinformatics is the combination of information technology, statistics, molecular biology, and algorithms to analyze the data obtained from various experiments. It includes collecting biological data, preparation of a computational model, solving computational modeling problems, and evaluation of computational algorithm. Bioinformatics uses computation to extract knowledge from biological data, which can be used in drug discovery and developments. The global bioinformatics market is expected to register substantial growth in the near future, owing to rise in need for integrated data and increase in applications of proteomics & genomics. In addition, drug discovery & development is... Read More

Recent Advances in Pancreatic Disorders & Therapy

Image New approach to pain treatment in diseases of the pancreas One of the worst symptoms associated with inflammation or cancer of the pancreas is severe chronic pain. Pancreatic pain is difficult to treat, because many painkillers prove ineffective in pancreatic patients. In a recent study, a team at the Technical University of Munich (TUM) discovered the cause of this phenomenon for the first time: a particular neuroenzyme in the body is present in the nerves of the organ in high concentrations. In many cases only potent analgesics such as opiates are able to relieve the suffering of those affected. But... Read More

Latest Research in Pancreatic Disorders & Therapy

Image The pancreas is a large gland in the abdomen. It secretes pancreatic juices into the small intestine to digest food, and secretes insulin into the bloodstream to regulate glucose levels. The pancreas is both an endocrine gland (releasing juices directly into the bloodstream) and an exocrine gland (releasing juices into ducts). Microbiota in pancreatic health and disease: the next frontier in microbiome research Diseases intrinsic to the pancreas such as pancreatitis, pancreatic cancer and type 1 diabetes mellitus impart substantial health and financial burdens on society but identification of novel mechanisms contributing to these pathologies are... Read More

Pathophysiology of Concurrent Trauma and Exsanguination

Image Trauma continues to remain the leading cause of morbidity and mortality in the developed countries. Hemorrhage is the second most common cause of death after trauma, only outnumbered by traumatic brain injury. Exsanguinating hemorrhage is the most common cause of mortality in the first hour of arrival to a trauma center and accounts for almost half of deaths in the first 24 h. In addition,  about  20-40%  of  trauma  deaths  that  occur after  hospital admission  usually  involve  massive  hemorrhage,  in  which  death  is potentially preventable. Although the resuscitation protocols and management  strategies  for  resuscitation  of  patients  with exsanguinating  hemorrhage  have ... Read More

Instructions for Authors for Submission Manuscripts- Transcriptomics: Open Access

Image TranscriptLongdom Publishing is a total set of transcripts in a given organism and referred to as an expression profiling that examines the expression level of mRNAs in a given cell population. TranscriptLongdom Publishing includes high-throughput techniques based on DNA microarray. TranscriptLongdom Publishing:Open Access Journal is at higher echelons that enhance the intelligence and information dissemination on topics closely related to TranscriptLongdom Publishing. They provide a unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on an array of TranscriptLongdom Publishing. TranscriptLongdom Publishing:Open Access Peer Reviewed Journal is proficiently supported... Read More

Latest Published Paper-Journal of Astrobiology and Outreach

Image The Recent published article in the Journal of Astrobiology and Outreach was an Editor note “Our Fascination with Mars” written by Gary Boyle. Ancient mythology refers to it as the God of War. Tuesday, the second day of the week, is translated from the Latin ‘dies Martin’ and from French ‘mardi’. In fact the seven days of the week come from the five wandering planets, the Sun and Moon. It has been the love of science fiction writers and movie makers. Commonly known as the red planet, Mars has always had to extra bit... Read More

Published Article: Journal of Astrobiology & Outreach

Image The very first published article in the Journal of Astrobiology and Outreach was an editorial entitled “Does Space Weather Matter to Astrobiology? The International Space Weather Initiative” written by Hans J Haubold Space weather events can have significant effects all the way from the Sun to Earth. They have been implicated in the depletion of ozone and cloud formation, and their signatures may even be seen in ice core records spanning more than 400 years into the past. Solar activity at other planets, and elsewhere in the solar system, can be important, and violent... Read More

H5N1 Protection by Seasonal Influenza Vaccine

Image A number of different approaches aimed at broadening the cross-protective ability of seasonal influenza vaccines are being explored today. Priming a seasonal vaccine with three administrations of DNA encoding H1 HA corresponding to the HA in the seasonal vaccine has been shown to confer protection against heterologous H1N1 influenza. Here we evaluated the heterosubtypic protection induced by a seasonal influenza vaccine when primed with H1 HA DNA and, in parallel, when given as a homologous prime/boost regimen. Balb/c mice were immunized three times with vaccine homologous H1 HA DNA prior to a boost with seasonal influenza vaccine (season 2009/2010; Northern... Read More

Neospora caninum Immunogens against Neosporosis

Image Neospora caninum, the parasite that causes neosporosis, is known worldwide as one of the main drivers of abortion in cattle herds, causing economic losses when raising livestock. Parasitic infection and transmission among animals are difficult to combat, and both diagnostics and controls must be applied to reduce the spread of the pathogen. For control, herd vaccinations represent an alternative, but the current lack of a safe and effective vaccine prevents this method. The parasite has a significant array of structural proteins that assist in the process of infection; surface antigens (SAGs), microneme proteins (MICs), dense granule antigens (GRAs) and rhoptria... Read More

Drug Designing

Image  Drug Designing: Open Access   Gives dependable data upgrade to online viewers with the adapted methods and most advancement in the field on designing new drugs, research and developments, clinical experiments, drug delivery systems, and adverse events, biochemistry and pharmacological aspects. The idiosyncratic reactions are unpredictable from the pharmacological action of the drug. Genes are also associated with ADRs; genes that consistently exhibit increased or decreased expression during these toxic responses in model systems serve as biomarkers to predict potential adverse effects. Hepatotoxicity and nephrotoxicity are two major reasons that drugs are withdrawn post-market. Other important ADRs affect... Read More

Reflections on Clinical Ethics

Image During the course of my career as a child neurologist and faculty member of the Johns Hopkins Berman Bioethics Institute, I have developed a familiarity with the various moral philosophies: Utilitarian, Aristotelian, Kantian, but have found that they rarely enter my thinking or language as I make difficult clinical decisions at the bedside. They seem much like the field of biochemistry, useful as background, but rarely of use at the bedside. I am clearly a Utilitarian clinician striving to produce the greatest good for the greatest number, but that number is always constrained to the individual family and child at... Read More

Drug: Discovery Research

Image The Journal Drug Designing: Open Access aims to fill this important knowledge barrier for decades. Here the Journal tries to provide a platform for them to meet their existence with the commitment to the research society by publishing their latest research. The Journal has been dealing with the case reports, original research and review articles about the pharmaceutical intervention safety, side effects, and adverse effects as well as medication toxicity. Drug Discovery Research focuses on the latest research in all related fields of drug targets, rational drug discovery, computer-aided drug design and the different types of drug design, development... Read More

International Biomedical Research and Research Ethics Training in Developing Countries

Image Background: In recent years, international research collaborations have been growing rapidly. Multinational pharmaceutical companies and academic institutions have expanded their research to developing countries. This in part is driven by the increased awareness of health as a global issue, the challenges imposed by new and resurgent global epidemics, the increased demand for new treatments, and practical and financial considerations of the pharmaceutical industry. For example, a sharp increase in research in developing countries is largely due to the global HIV/AIDS epidemic and increased efforts to control malaria epidemic . In addition, institutions within developing... Read More

Ovarian Cancer - The Silent Killer

Image Ovarian Cancer - The Silent Killer Abstract Ovarian cancer is heterogeneous, multigenetic and epigenetic abnormalities and lethal among all other gynecological women malignancies amongst women. Moreover, ovarian cancer has a distinct biology and behavior at cellular and molecular level. According to National Cancer Institute’s Surveillance, Epidemiology and End Result Program Report in 2017 the new case of ovarian cancer exacerbated to 22.4% from 11.7% in 2014. The Therapeutics use of cancer therapies has been restricted due to its nonspecific and dose limiting cellular toxicity and development of multidrug resistance. To overcome the restriction various biotechnological therapies and drug delivery system... Read More

Journal of Tumor Research: A strategy document from the NCRI Brain Tumor CSG

Image Journal of Tumor Research: A strategy document from the NCRI Brain Tumor CSG Abstract The National Cancer Research Institute (NCRI) is a partnership of charity and government research funders whose purpose is to improve health and quality of life by accelerating progress in cancer-related research through collaboration. Under this umbrella, the NCRI Brain Tumor Clinical Studies Group is focused on improving clinical outcomes for adult patients with brain and central nervous system tumors, including those with brain metastasis from other primary sites. This document discusses the current state of clinical brain tumor research in the United Kingdom and the challenges... Read More

Journal of Surgery and Anesthesia Announces discount on membership and extends the time to 24th of January

Image Journal of Surgery and Anesthesia is a peer reviewed, open access journal dedicated to publishing research on all aspects of surgery and anaesthesia. This journal aims to keep anaesthesiologists, anaesthetic practitioners, surgeons and surgical researchers up to date by publishing clinical & evidence based research. Journal of Surgery and Anesthesia addresses all aspects of surgery & anesthesia practice, including anesthetic administration, pharmacokinetics, preoperative and postoperative considerations, coexisting disease and other complicating factors, General Surgery, Robotic Surgery, Orthopedic Surgery, GI Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Urology, Surgical Oncology, Radiology, Ophthalmology, Pediatric Surgery, Trauma Services, Minimal... Read More

View on Food microbes -Applied Microbiology: Open Access

Image View on Food microbes -Applied Microbiology: Open Access Applied Microbiology: Open Access is a scholarly open access journal that deals with the study of Medical microbiology the study of the pathogenic microbes and the role of microbes in human illness, Pharmaceutical microbiology the study of microorganisms that are related to the production of antibiotics, enzymes, vitamins and vaccines, Industrial microbiology the exploitation of microbes for use in industrial processes It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the... Read More

Instructions for Authors for Submission Manuscripts :Applied Microbiology

Image Instructions for Authors for Submission Manuscripts :Applied Microbiology Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the form of Research, Reviews, Commentaries, Letter to Editor, Case Reports, Short Communication, Images, Conference Proceedings which will  be... Read More

QUANTUM COMPUTING: THE FUTURE

Image On behalf of the Journal, as Editor-in-Chief, it is my distinct honour and privilege to welcome you to the Journal of Theoretical and Computational Science. The Journal of Theoretical and Computational Science aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Modern Scientific Techniques. The open access journal is published by Longdom Publishing who hosts open access peer-reviewed journals as well as organizes conferences that hosts the work of researchers in a manner that exemplifies the highest standards in research integrity. I would like to... Read More

Probiotics in Gastroenterology

Image Perturbation of bacterial microflora of the gastrointestinal (GI) tract may play an important role in the pathophysiology of some GI disorders. Probiotics are dietary supplements that have shown potential benefit in the treatment and prevention of various gastrointestinal (GI) disease states.  GI Microbiota-The term microbiota refers to a community of microorganisms populating one defined environment. The majority of human gut microbiota consists of members of bacterial phyla such as Bacteroidetes, Firmicutes, Proteobacteria, and Actinobacteria, with many species of anaerobic, commensal bacteria still being specifically identified. Probiotics restore normal bacterial microflora and effect the functioning... Read More

Gene Expression - RNA to protein

Image Gene Expression - RNA to protein Genes encode proteins and proteins dictate cell function. Therefore, the thousands of genes expressed in a particular cell determine what that cell can do?. Moreover, each step in the flow of information from DNA to RNA to protein provides the cell with a potential control point for self-regulating its functions by adjusting the amount and type of proteins it manufactures. At any given time, the amount of a particular protein in a cell reflects the balance between that protein's synthetic and degradative biochemical pathways. On the synthetic side of this balance,... Read More

Gene Syndrome

Image Gene Syndrome Journal of Genetic Syndromes & Gene Therapy (JGSGT)  brings articles in all areas related to Genetics such as Genetic disorders, Genetic mutations, Auto immune diseases etc on Quaterly basis. JGSGT welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately 7 days after acceptance. https://www.longdom.org/genetic-syndromes-gene-therapy.html Journal of Genetic Syndromes & Gene Therapy has NLM ID: 101574143 Index Copernicus Value 2016: 84.15, Journal Impact Factor 2.34*,  ISSN: 2157-7412. The Scientists, Professors, Research scholars, Doctors... Read More

Commentary on “Gallbladder Cancer: South American Experience

Image Commentary on “Gallbladder Cancer: South American Experience When I was invited by Dr. Ghassan Abou-Alfa to write an article about the South American experience in gallbladder cancer (GC) I felt enthusiasm. It was an opportunity to make a contribution to this public health problem. GC is among the leading causes of death from cancer in women in many Western areas in my country Argentina and in South America.  Based on their daily practice experience many health workers in Salta, the province where I live at the northwest of Argentina, know that GC is a local public health problem. So,... Read More

MicroRNAs in Skin Biology: Biogenesis, Regulations and Functions in Homeostasis and Diseases

Image MicroRNAs in Skin Biology: Biogenesis, Regulations and Functions in Homeostasis and Diseases The progression in science gives novel and deeper understandings of human beings organisms. The Human Genome Project uncovered about 20,500 human genes. More recently, non-coding RNAs saw the light and gained researchers interest. Among the different subsets of these non-coding RNAs, microRNAs were identified as 18-25 nucleotides long and have been shown to play critical regulatory roles in a wide range of cellular processes. Emerging studies highlighted the importance of miRNAs in health and in disease. Ten years ago, the role of miRNAs in cutaneous system has been... Read More

Acute Renal Failure

Image ARF is common in the setting of critical illness and is correlated with a high risk of mortality. The aim of this study was to determine the risk factors and short term outcome of Acute Renal Failure (ARF) in intensive care unit (ICU). This study was designed as an analytic cross-sectional study. First, 201 Patients who hospitalized in the ICU enrolled in this study. ARF was defined as a plasma creatinine levels according to Acute Kidney Injury Network (AKIN) criteria.The assessed risk factors of ARF were age, gender, Cause of hospitalization in the ICU, Imaging with Contrast agents, mechanical ventilation,... Read More

Solpugidophobia : Real or Illusion

Image Having fear and anxiety is necessary in any animal, for their survival. In humans, fear cause they behave reliable and safe. The nature of anxieties and fears changes with increasing age and learning knowledge. Fear or phobia of animals such as snakes, Zoophobia, Herpetophobia, scorpions, arachnids, Archnophobia, insects and Entomophobia is common. Entomophobia is an unusual fear of insects that may cause psychological problems in individuals at critical situation, which needs effective treatment. If these feelings of fear and anxiety be stable, may affect people's mental health. Anxiety caused by fear, will have long-term effects. Fear of arachnids and insects... Read More

Cerebellar Ataxia in HIV Patient

Image Acute cerebellar ataxia (ACA) is a disorder that occurs when the cerebellum becomes inflamed or damaged. The cerebellum is the area of the brain responsible for controlling gait and muscle coordination. The term ataxia refers to a lack of fine control of voluntary movements. Here we present a case report of a rare presentation of efavirenz associated cerebellar ataxia in a patient of HIV/AIDS. Ataxia in a patient of HIV is generally secondary to an infectious, vascular or neoplastic cause. Most infections are opportunistic and unlikely to occur when CD4 levels are adequate. Focal lesions resulting from opportunistic infections such... Read More

Cloning, Expression and Purification of Recombinant Forms

Image Full length Ebolavirus glycoprotein (GP) intersperses the outer most lipid membrane to form spikes, where it mediates virus-host cell interaction. A secretory form of GP (sGP) is also produced by all 5 known Ebolavirus species. These attributes make GP an ideal target for research and development (R and D) of Ebolavirus and possibly pan-filovirus targeted Rapid Diagnostic Tests (RDTs), bio-therapeutics and vaccines. Prior cloning of recombinant Zaire ebolavirus (EBOV) GP has majorly used insect (baculovirus ) expression systems. We report the cloning, expression and purification of the full length and extracellular domain (ECD) forms of recombinant EBOV GP in mammalian cell-lines. 2034 and 1956 base-pair (bp) coding... Read More

Rheumatology and its world

Image A recently created apparatus to break down the cell and sub-atomic profiles of synovial tissue and fringe blood may help open signs about rheumatoid joint inflammation and lead to better treatments. Rheumatoid joint pain (RA) is an interminable ailment that causes torment, firmness, expanding, and constraint in the movement and capacity of different joints. In spite of the fact that joints are the chief body parts influenced by RA, aggravation can create in different organs too. An expected 1.3 million Americans have RA, and the illness regularly influences ladies twice as frequently as men. APS is a fundamental immune system... Read More

Clinical-Therapeutic Importance of Bioimpedance in Patients with Lymphedema

Image Clinical-Therapeutic Importance of Bioimpedance in Patients with Lymphedema Introduction: Lymphedema is characterized by abnormal accumulation of macromolecules and soft tissue fluids. Bioimpedance is a method that measures intra- and extracellular volumes by body segment, and has been currently used in lymphedema. Objective: The objective of this study was to conduct a systematic review of the clinical-therapeutic importance of bioimpedance in patients with lymphedema. Methodology: The present work consisted of a literature review. The systematic review made it possible to know and transcribe important subjects on clinical and therapeutic bioimpedance in patients with lymphedema. The work was carried out from September... Read More

Parathyroid Carcinoma has a PD-L1 Expression, and Share with Atypical Neoplasms an Abundant Intratumoral Macrophagic

Image Parathyroid Carcinoma has a PD-L1 Expression, and Share with Atypical Neoplasms an Abundant Intratumoral Macrophagic Aim: The aim of this study was characterized programmed death-ligand 1 (PD-L1) expression and tumoralinfiltrating lymphocytes (TILs) in parathyroid carcinoma (PC) and atypical parathyroid neoplasms (ANs). Methods: Our tissue samples constitute 30 parathyroid tumors (17 PC and 13 ANs) which were available from a prospectively collected database at the University of Texas M.D Anderson Cancer Center from 1996 to 2016. All samples were meticulously reviewed utilizing the current World Health Organization histopathological criteria. Each of the samples was immunohistochemically analysed for PD-L1, CD3, CD8... Read More

Science behind life origin (Astrobiology)

Image On behalf of the Journal of Astrobiology & Outreach, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, our journal running 5th volume by welcoming Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of Astrobiology & Outreach. The Journal of Astrobiology & Outreach aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Astrobiology. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals... Read More

Research on Astrobiology

Image Journal of Astrobiology & Outreach is currently running 5th volume by welcoming Analytical Society to our journal.The Journal of Astrobiology & Outreach aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Astrobiology. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. Journal of Astrobiology & Outreach (JAO), a broad-based journal was founded on two key tenets: To publish the most exciting researches with respect to the subjects of... Read More

Tranexamic Acid and Major Spine Surgery Trends and Controversies

Image The beneficial role and efficacy of Tranexamic Acid in reducing perioperative blood loss and blood transfusion equirements in spine surgery is being established. Tranexamic Acid is an anti fibrinolytic agent traditionally used tolessen perioperative blood  loss.  Tranexamic Acid can be administered orally, intramuscularly, intravenously ortopically. Tranexamic Acid studies in spine surgery have limited patient enrolment. Most of the reported studies have mixed results and difficult to interpret. The efficacy of anti fibrinolytic agents is evident in a wide variety of surgicalprocedures: liver transplantation, obstetrics and gynaecology, trauma and orthopaedic surgical procedures. The effect of Tranexamic Acid on the occurrence of... Read More

Gene Expression

Image Gene Expression Visakhapatnam, 29-11-2019 On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy. The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. Journal of Genetic Syndromes &... Read More

Evolutionary Trends in Gene

Image Evolutionary Trends in Gene Visakhapatnam, 29-11-2019 The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy. The genetic information lies within the cell nucleus of each living cell in the body. The information can be considered to be retained in a book for example. Part... Read More

Genomic Strategies for Global Health

Image Tumor Genomics Tumor Genomics is the investigation of hereditary transformations in charge of malignancy, utilizing genome sequencing and bioinformatics. Disease genomics is to enhance growth treatment and results lies in figuring out which sets of qualities and quality associations influence diverse subsets of tumors. Universal Cancer Genome Consortium (ICGC) is a deliberate experimental association that gives a discussion to joint effort among the world's driving growth and genomic analysts. Utilitarian Genomics Utilitarian Genomics use incomprehensible abundance of information created by genomic transcriptomic tasks to portray quality capacities and cooperations. Patterns in Functional... Read More

Bone Tumors

Image Bone Tumors Bone tumors grow when cells in the bone divide without control, forming a mass of tissue. Most bone tumors are benign, which means they are not cancer and do not spread to other areas of the body. But they may still weaken bone and lead to broken bones or cause other problems. Bone cancer destroys normal bone tissue. It may start in the bone or spread from other parts of the body (called metastasis). Benign Bone Tumors Benign tumors are more common than tumors caused by cancer. These are a few common types of benign bone tumors: Osteochondroma... Read More

Computer-aided design of inhibitors of DNA methyl transferases

Image The team “Drug Designing: Open Access”, welcomes you to the most accessed “open access publication – Longdom Publishing” page with 25+ Million reader base. The Journal of Drug Designing: Open Access progresses forward reviewing and disseminating the recent advances in pharmaceutical industry with focus towards the drug discovery, drug design by rational approach. Longdom Publishing hosts around 215 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases (DNMTs). DNMT inhibition is a promising strategy for the epigenetic treatment of cancer... Read More

Specificity of Heparin/Heparan sulphate binding to proteins

Image The Journal, Drug Designing: Open Access publishes the highest quality scientific articles amalgamating broad range of fields including molecular modeling, clinical research and drug discovery and delivery. Heparin/heparan sulphate? Protein interactions modulate a number of physiological processes such as coagulation, immune response, angiogenesis, and morphogenesis and pathogen infection. A majority of these interactions involve allosteric regulation of the target protein and are poorly understood. We have developed a genetic algorithm-based combinatorial virtual screening approach to understand the nature of interaction of heparin/heparan sulphate with proteins. A dual-filter strategy employing an ?affinity? filter followed by a ?specificity? Filter... Read More

Racial Differences in Hospital Stays among Patients Undergoing Craniotomy for Tumour Resection at a Single Academic Hospital

Image Racial Differences in Hospital Stays among Patients Undergoing Craniotomy for Tumour Resection at a Single Academic Hospital Study design and selection of patients We conducted a retrospective cross-sectional study that included adult patients (18 years or older) who underwent craniotomy for brain tumour resection at a single academic medical centre in Los Angeles, California from March 2013 to January 2017. Patients were selected using International Classification of Diseases, 9th and 10th Revision and Current Procedural Terminology, version 4 codes. Informed consent was obtained from all individual participants included in the study. The study had prior approval from our institutional review... Read More

Applied Microbiology: Open Access- Invitation on Special Issues

Image Applied Microbiology: Open Access- Invitation on  Special Issues Applied Microbiology: Open Access is a scholarly open access journal that deals with the study of Medical microbiology the study of the pathogenic microbes and the role of microbes in human illness, Pharmaceutical microbiology the study of microorganisms that are related to the production of antibiotics, enzymes, vitamins and vaccines, Industrial microbiology the exploitation of microbes for use in industrial processes It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the... Read More

Applied Microbiology: Google scholars

Image Applied Microbiology: Google scholars Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the form of Research, Reviews, Commentaries, Letter to Editor, Case Reports, Short Communication, Images, Conference Proceedings which will  be published in our journal.... Read More

A keen approach for Collective Consciousness

Image The Artificial Intelligence is intended to present within a single forum all of the developments in the field of multi-sensor, multi-source, multi-process information fusion and thereby promote the synergism among the many disciplines that are contributing to its growth. Abstracts are invited on the various topics like Data/Image, Feature, Decision, and Multilevel Fusion, Multi-classifier/Decision Systems, Multi-Look Temporal Fusion, Multi-Sensor, Multi-Source Fusion System Architectures Distributed and Wireless Sensor Networks. Neural systems Artificial Intelligence covers information processing in natural and artificial neural systems. The conference presents a fresh, unidiomatic attitude towards this multi-disciplinary... Read More

Multi-layer Explosion Based Fireworks Algorithm

Image We propose a new multi-layer explosion strategy inspired by various explosion patterns of real reworks to accelerate reworks algorithm (FWA). Each rework individual conducts multiple explosions to explore a local fitness landscape carefully instead of a single layer explosion used in canonical FWA. In the proposal, each firework individual generates a small number of sparks in the first layer randomly, and then the generated sparks conduct the second layer explosions to generate new diverse sparks. These new sparks repeat the above operations until the number of this iteration reaches the predefined maximum layer number.... Read More

Evaluating and implementing a new Technology in vision and Ophthalmology

Image Ophthalmology is a stream of medicine dealing with eye and visual system. Ophthalmology completely relates to both internal visual system and external parts such eye ball, eye lid, eye lashes and tear formation. Treatments include right from external eye care to using medical, surgical and rehabilitate methods to treat various eye related problems. Many specialists such as Ophthalmologists, Optometrists, Vision Specialists working on various aspects to eradicate blindness. To have blind free world, it is very important for the clinicians and researchers to meet and discuss about the various aspects to... Read More

World-wide Ophthalmology surgical devices

Image Our aim is to provide the surgeons, refractive surgeons, optometrists, opticians, young researchers, students, industrial delegates and anyone professionally involved in study of Ophthalmology and Eye care and surgery with an opportunity to learn about the complexity of the disease, discuss interventional procedures, look at new and advanced cataract removal practices and their efficiency and efficacy in the treatment of various refractive errors and cataract extraction, and understand local realities and practical constraints in improving vision-care. Ophthalmology Ophthalmology is that the specialty involved with the medical and... Read More

INTERNATIONAL JOURNAL OF NUTRITIONAL DISORDERS & THERAPY

Image International journal of nutritional disorders & therapy celebrates eight years of its existence in the field of medical publishing and research and extends a very warm welcome to all the authors, researchers, editors and student to contribute their latest research findings as full length articles to this collaborative medical journal. The journal is committed to serve its readers authors by adding the state of the art facilities to enhance the author’s scholarly visibility. Established in the year 2011, International Journal of nutritional disorders & therapy is one of the most reputed journals of LONGDOM group, the collaborative medical publisher,... Read More

Cell signalling recent research work

Image On behalf of the  Journal of  Cell Signaling , as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been four years we have started the Journal, now we are celebrating the 4th Anniversary and we are privileged to welcome Analytical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of  Cell Signaling Journal of Cell Signaling brings articles in all areas related to effector systems, such as protein kinases, lipid signaling pathways, cyclic nucleotide signaling processes, NO signaling and ion channels. The... Read More

Explore Novel Ideas in Natural Products and Chemistry

Image Natural Products Chemistry and research is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances.   The Journal is pleased to inform that it is been running successfully since 7 years and is running towards its 8th Anniversary. It is an Open access scholarly Chemistry and Natural Medicine journal with an ISSN No: 2329-6836. This journal is known for its quality research articles in the field of Agricultural Chemistry, Pharmacognosy, Alkaloids, Flavonoids, Bioactive compounds, Biochemistry, Physical Chemistry, Phytochemistry, Natural Medicine, Herbal Medicine, Phytomedicine, Marine drugs, Natural products and Horticulture. The journal is indexed in... Read More

Journal of Surgery and Anesthesia Invites Manuscripts

Image Journal of Surgery and Anesthesia is a peer reviewed, open access journal dedicated to publishing research on all aspects of surgery and anaesthesia. This journal aims to keep anaesthesiologists, anaesthetic practitioners, surgeons and surgical researchers up to date by publishing clinical & evidence based research. It would be our extreme pleasure to invite you to submit your manuscripts to our journal for our upcoming issue Volume 4, Issue 1. We would appreciate receiving your submission on or before January 20th, 2020 OR let us know your feasible time to extend the deadline. Your submissions... Read More

Advances in transcriptomics provide insights into brain disease and development

Image In recent years, technological advancements in transcriptomics (the process of studying a cell’s complete set of RNA transcripts) have provided new opportunities for researchers to study brain diseases and development at the single-cell level. This was highlighted by a series of abstracts, all presented recently at the SfN Neuroscience 2019 (Chicago, IL, USA; 19-23 October 2019), where researchers utilized transcriptomics to study the underlying cellular processes associated with addiction, degeneration and normal development. In the first presentation, Philipp Mews (University of Pennsylvania; PA, USA) explained how by using transcriptomics on mouse models of cocaine addiction, his team... Read More

Opsoclonus Raccoon Eye in Fatal Metastatic Neuroblastoma

Image Metastatic neuroblastoma with opsoclonus raccoon eye presentation is an extremely rare condition presented in stage IV metastatic condition. Histopathology/ cytology, vanillylmandelic acid (VMA), homovanillic acid (HVA) levels and metaiodobenzylguanidine (MIBG) scanning are mainly contributors for the diagnosis of this disease. We are presenting one year male child with history of protrusion of right eye, swelling in right periauricular region, opsoclonus movements of small amplitude and periorbital ecchymosis ‘raccoon eye’. So far only infinitesimal cases has been reported in the literature and our present case report is an extremely rare case of locally advanced metastatic neuroblastoma, who presented as opsoclonus raccoon... Read More

Machine Learning in Healthcare Data Analysis

Image In recent years, healthcare data analysis is becoming one of the most promising research areas. Healthcare includes data in various types such as clinical data, Omics data, and Sensor data. Clinical data includes electronic health records which store patient records collected during ongoing treatment. Omics data is one of the high dimensional data comprising genome, transcriptome and proteome data types. Sensor data is collected from various wearable and wireless sensor devices. To handle this raw data manually is very difficult. For analysis of data, machine learning is emerged as a significant tool. Machine learning uses various statistical techniques and advanced... Read More

HIV-Associated Tuberculosis in Russia

Image The goal of the work was to study the socio-demographic and clinical profile of the patients with TB/ HIV co-infection, as well as the treatment effectiveness to understand what shortcomings in the work of TB and HIV services are needed to be corrected. A retrospective study was performed among 377 patients with dual co-infection TB/HIV between January 2015 and December 2016. TB diagnoses were based on clinical symptoms, sputum microscopy, and radiological analyses. The patients were diagnosed as HIV seropositive by ELISA and by Western blot. Out of 377 individuals with co-infection HIV/TB there were 56.8% of patients with newly... Read More

Non-Structural Proteases as a Target of Dengue Virus

Image Dengue is a globally emerging health concern, still in preliminary stage of drug development. Many research scientists explored the dengue virus and identified its several targets that are categorized as structural and non-structural proteins, irrespective of its serotypic classification. A number of natural, synthetic and patented analogs are screened and studied against different serotypes and targets of dengue. Our review compiles the recent developments based on the huge number of such molecular space created by diverse scaffolds, specifically targeting NS2B-NS3 protease and methyltransferase (NS5) of dengue virus (DENV) infection. The emphasis of our article is to confer the leads... Read More

Mechanism of Low Endotoxin Recovery Caused by a Solution Containing a Chelating Agent and a Detergent

Image Mechanism of Low Endotoxin Recovery Caused by a Solution Containing a Chelating Agent and a Detergent Mechanism of Low Endotoxin Recovery (LER) was investigated by observing the change in particle sizes and activity of endotoxin in LER solutions containing sodium citrate and polysorbate 20. Interestingly, endotoxin aggregates were not dispersed to be smaller particles under LER conditions according to the decease of the activity. This observation was different from previous predictions of the mechanism. Endotoxin aggregates were observed by Dynamic Light Scattering, and activity was measured by the Limulus amebocyte lysate test. Particles with sizes similar to endotoxin aggregates were... Read More

The Search for New Vaccine Adjuvants

Image Journal of Vaccines & Vaccination is on the leading open-access journal making awareness to the people on vaccination through our articles. We have been publishing the articles which are having updated information about the vaccine's treatment diseases. Immune Response Modifying Effects of Bee Venom Protein [Melittin]/ Autoclaved L. donovani complex in CD1 Mice: The Search for New Vaccine Adjuvants. Visceral leishmaniasis (VL) is a major cause of morbidity/mortality in remote areas of East Africa. Vaccines for VL can provide an effective control measure to help control/eliminate this fatal disease. To date, there is no... Read More

Application of Cancer Stem Cell-Targeted Vaccine in Cancer Immunotherapy

Image Accumulating evidence shows that tumours contain a distinct subpopulation of cancer stem cells (CSCs) which are capable of self-renewal, differentiation, and tumour-initiation. Previous studies have demonstrated that cancer stem cells are relatively resistant to chemo-and radio-therapies, and play an essential role in tumour recurrence and metastasis. Since multiple human malignancies are associated with quantitative and qualitative deficiencies in the immune system, immunotherapies are potentially ejective for cancer treatment. Vaccination is believed to have advantages over traditional treatments due to its potential to possibly eradicate the micrometastases that tend to linger after standard treatments. However, to date, experimental evidence remains limited... Read More

Chronic Abdominal Pain following the TAPP Hernioplasty, Caused by Appendix Attached to the Polypropylene Mesh

Image Chronic Abdominal Pain following the TAPP Hernioplasty, Caused by Appendix Attached to the Polypropylene Mesh We report a case of 42 y old male patient with chronic pain in the lower right abdominal quadrant that appeared almost every time after or during exercise, for a last two years. The patient underwent transabdominal preperitoneal patch hernioplasty (TAPP), due to the right inguinal hernia two and a half years ago. There were no comorbidities or other previous operations in his medical records. Since the abdominal ultrasound (US) and magnetic resonant (MR) with laboratory methods did not show any special findings, the laparoscopy... Read More

Special Issue Guidelines for Hair Therapy and Transplantation

Image Special Issue Guidelines for Hair Therapy and Transplantation Longdom Publishing SL welcomes proposals for special issue that falls within the scope of the Hair Therapy and Transplantation Journal. The special issue aims at exploring new, relevant, and the most compelling dimensions in the field of Hair Therapy and Transplantation that missed a mention in the journal on a regular basis. Proposal Preparation Special issues will be released on a monthly basis and proposals will be accepted accordingly. All proposals should include the following information: Title of the proposed special issue Purpose and current relevance List of topics to be... Read More

Complexity in Bioethics

Image Complexity (L-complexitas) is perhaps the most essential characteristic of our present day global networking interdependent society. The traditional scientific method, which is based on analysis, isolation, and the gathering of complete information about a phenomenon, falls short when dealing with such complex interdependencies. Belgian cyberneticist Francis Paul Heylighen use of the emerging science of ‘complexity’ as an alternative methodology capable of tackling such problems. In philosophical context, the science of complexity is based on a new way of thinking standing in contrast to Newtonian science which is primarily based on reductionism, determinism and objective knowledge. Newton believed his... Read More

Celebrating 10 Glorious Years of Excellence in Clinical Research and Bioethics

Image Journal of Clinical Research and Bioethics (ISSN: 2155-9627) is scheduled to celebrate its 10th anniversary in the year 2020. The journal is devoted to convey and spread to its researchers around the world, the latest knowledge on General Ethics, Animal Ethics, Medical Ethics, Clinical Ethics, Nursing ethics, General Ethics, Clinical and Medical research etc. The Journal is offering special discounts up to 35% on the article processing charges on the occasion of its 10th Anniversary and encourages the contributors across the globe to make the best use of the opportunity. All published articles of this journal are... Read More

Journal of Cell Signaling

Image The Journal is successfully running in the 4th Volume which covers a wide variety of specialties including Signal Transduction Cascades, NO Signaling and Ion Channels, Mapk Pathway Cell Signaling, Cancer Signaling Array, Signal Transduction reaching out to analytical scientists worldwide. The Journal of Cell Signaling accepts all types of articles including research, review, case reports, commentaries, hypotheses, meeting reports and short reports. This scientific journal is using Editorial Tracking System for maintaining quality in peer review process. Review processing is performed by the editorial board... Read More

Plants give Life to Soul

Image Journal of Plant Biochemistry & Physiology is celebrating 7th Anniversary it’s been seven years we have started the Journal. The open access journal is published by Longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. We are privileged to welcome researchers to our journal. Journal accept all topics related to Biochemistry physiology of plants. Journal of Plant Biochemistry & Physiology started handling different types of article like research, review, case report, mini review, short commentary, rapid communication, image articles since 2013. Journal released 6 issues in volume... Read More

Journal of Thyroid Disorders and Therapy Announces Reasonable Discounts

Image Journal of Thyroid Disorders and Therapy Announces Reasonable Discounts Journal of Thyroid Disorders and Therapy has announced almost 50 percent discount on article processing charge to commemorate its Anniversary. Journal of Thyroid Disorders and Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to thyroid disorders and therapy. The open access journal is published by the Lexis Group comprising of Lexis Academy and Lexis Press, has come a long way in publishing sector. Currently, the Lexis group operates from its headquarters in Brussels, Belgium, and regional... Read More

Long Survival Colon Cancer: The Key is Multidisciplinary Treatment

Image Long Survival Colon Cancer: The Key is Multidisciplinary Treatment Colorectal cancer is one of the most common diseases of the Western countries. Нe incidence of colorectal cancer (CRC) in Spain in 2012 was 19261 cases in males and 12979 in females, and it was the second largest cause of cancer mortality in both sexes. More than 25% of patients are diagnosed with advanced disease, and 25% of patients with early stages have a relapse during the follow-up. Of these, 80%-90% have unresectable liver metastatic disease. Despite the sLJnLficant... Read More

Palliative Care: An Alien Concept in Pakistan

Image Commentary This paper is based on a scenario of a 30-year old young man with end-stage lymphoma. Нe mother wanted to do all possible interventions to treat his son. Нe medical team concluded that there is no further treatment option available. Нe physician wanted to send the patient home to spend time with his family and to prevent hospital induced complications, whereas the mother was not willing to take him home. In such situation, what would be the possible best decision for the patient who has a short expected survival time? Нe analysis of the above case study highlighted... Read More

Advanced Scientific Survey on Forensic Pathology

Image Forensic pathology is a specific branch of medicine that focuses on determining the cause of death by examining a corpse. A post mortem is performed by a medical examiner, usually during the investigation of criminal law cases and civil law cases in some jurisdictions, the principles and knowledge of medicine and related sciences to problems that concern the general public and related legal issues. A forensic pathologist is a physician with specialized medical and forensic science training and knowledge. In practice, forensic pathologists concentrate closely on the understanding of types and causation of injuries and causes of sudden and unnatural death. The roles of the forensic pathologists includes examination of the death... Read More

Latest trends in Cancer Research and Immuno-Oncology

Image Journal of  Cancer Research and Immuno- Oncology is an international, peer-reviewed journal which publishes high quality manuscripts from basic, fundamental, applied research developments in cancer research and its immunology. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. The main aspects of research areas include, but are not exclusive to cancer biology, tumor, radiology, metastatis, cancer immunotherapy, oncology, radiation therapy etc.,   Editorial Board of Agrotechnology journal consists a group of prominent personalities with expertise in field who can add value to the existing research.   The... Read More

Journal Immunotherapy: Open Access announces invitations for editorial board

Image Immunotherapy: Open Access is an open access peer reviewed journal which ardent to promote and publish novel research findings and reviews of already published novel works. Immunotherapy: Open Access does this fast-track rapid peer review with the help of eminent reviewers and editors.   The editorial board formed with the eminent researches throughout the globe with maximum geographical distribution. All the editors are highly qualified as professors and research scientists. They will review under double blinded review process.   Immunotherapy is a treatment procedure... Read More

Scientific Survey on Natural Products and Research in Chemistry

Image   Natural Products Chemistry and Research is an open access Scientific Journal which mainly focuses on articles of Chemistry. The Journal of Natural Products Chemistry and Research comes up with an opportunity to researchers and scientist to explore advance research in Chemistry. The Natural Products Chemistry and Research is of highest standards in terms of quality.   The editorial team of Natural Products Chemistry and Research is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal. During this year we look forward to taking some initiates that would encourage and reward our... Read More

Explore Novel Ideas in Developing Drugs

Image Journal of Developing Drugs is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances.   The Journal is pleased to inform that it is been running successfully since 8 years and is running towards its 9th Anniversary. It is an Open access scholarly Developing Drugs journal with an ISSN No: 2329-6631. This journal is known for its quality research articles in the field of Pharmaceutics, Nanotechnology, Novel Drug Delivery Systems, Quality Control, Quality Assurance, International Regulatory, Validation Techniques, Industrial Pharmacy, BioTechnology, Bioinformatics, Proteomics, Biochemistry, Pharmacognosy, Pharmaceutical Analysis, PK/PD, Drug Development, Pharmacology and Toxicology, Pharmacy... Read More

“Reviewing the progression in Pharmaceutical research involving the metabolites”

Image The team “Pharmaceutical Analytical Chemistry: Open Access”, welcomes you to the most accessed “open access publication – Longdom Publishing” page with 25+ Million reader base. “Pharmaceutical Analytical Chemistry: Open Access” progresses forward reviewing and disseminating the recent advances in pharmaceutical industry with focus towards the metabolites. Longdom Publishing hosts around 215 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. “Pharmaceutical Analytical Chemistry: Open Access” is a peer-reviewed journal accepting research papers on topics related to ... Read More

Drug Abuse among Health Care Providers

Image Introduction I would like to commence my commentary article with the most frequently asked question in every society that why does man become a drug addict? Нe answer is that, one usually does not intend to become an addict. Someone woke up in the morning and become a drug addict, studies has shown that it takes at least three months’ shooting twice a day to get any habit.  Studies have proven that mostly drugs addict’s start taking narcotics without any reason (WHO, 2011).Drug addiction is a chronic, deteriorating brain disease that causes compulsive drug seeking and use,... Read More

Exploring the Inventions and Excellence in Artificial Intelligence and Machine Learning

Image Information fusion The Artificial Intelligence is intended to present within a single forum all of the developments in the field of multi-sensor, multi-source, multi-process information fusion and thereby promote the synergism among the many disciplines that are contributing to its growth. Abstracts are invited on the various topics like Data/Image, Feature, Decision, and Multilevel Fusion, Multi-classifier/Decision Systems, Multi-Look Temporal Fusion, Multi-Sensor, Multi-Source Fusion System Architectures Distributed and Wireless Sensor Networks. Neural systems Artificial Intelligence covers information processing in natural and artificial neural systems. The conference presents a fresh, unidiomatic attitude towards... Read More

International Journal of Swarm Intelligence and Evolutionary Computation have Exclusive Offer “Free Annual Publication with One Time Membership Fee”.

Image Journal of Swarm Intelligence and Evolutionary Computation ( Impact Factor 1.65*) has announced Annual Membership with exclusive discount on article processing charge to commemorate on its Anniversary. International Journal of Swarm Intelligence and Evolutionary Computation (SIEC) is an Open access academic journal that encompasses a wide range of current research on intelligent manufacturing systems, integrated process planning and scheduling, Computational Intelligence, bio-inspired computing, artificial intelligence, soft computing, swarm intelligence, evolutionary computation and other related fields and offers a promising platform for the authors to make their valuable contributions towards the journal. The Editorial Board of International Journal of... Read More

Advanced & Latest Innovations of Eye care for Future Vision

Image Our aim is to provide the surgeons, refractive surgeons, optometrists, opticians, young researchers, students, industrial delegates and anyone professionally involved in study of Ophthalmology and Eye care and surgery with an opportunity to learn about the complexity of the disease, discuss interventional procedures, look at new and advanced cataract removal practices and their efficiency and efficacy in the treatment of various refractive errors and cataract extraction, and understand local realities and practical constraints in improving vision-care. Ophthalmology Ophthalmology is that the specialty involved with the medical and... Read More

Journal of Eye Diseases and Disorders have Exclusive Offer “Free Annual Publication with One Time Membership Fee”.

Image Journal of Eye Diseases and Disorders (ISSN: 2684-1622) has announced Annual Membership with exclusive discount on article processing charge to commemorate on its Anniversary.  Journal of Eye Diseases and Disorders (JEDD) is an Open access academic journal that encompasses a wide range of current research on Clinical Sciences, Corneal transplant, Diabetic Retinopathy, Dry eye, Glaucoma and Diabetes, Intraocular Pressure, Lazy Eye, Malignant Glaucoma, Natural Remedies for Glaucoma, Night blindness, Ophthalmoscopy, Retinal detachment cells research and other related fields and offers a promising platform for the authors to make their valuable contributions towards the journal. The Editorial Board of Journal... Read More

Google Analytics of Applied Microbiology: Open Access

Image Google Analytics of Applied Microbiology: Open Access   Applied Microbiology: Open Access (Longdom Publishing S.L) has announced almost 50 percent discount on article processing charge. It’s our privilege to recite you as a foremost strategist in the realm of research and invite you to endowment your research penmanship and publication in forth coming issue in the form of Research, Reviews, Commentaries, Letter to Editor, Case Reports, Short Communication, Images, Conference Proceedings which will  be published in our journal Journal of Applied Microbiology (AMOA) is an open access, peer-reviewed journal that focuses on all... Read More

Applied Microbiology: Open Access-Reviewer Invitation

Image Applied Microbiology: Open Access-Reviewer Invitation Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. Applied Microbiology: Open Access follows Editorial Tracking System for quality in peer review process. Editorial Tracking is an online manuscript submission, review and tracking systems used by most of the best open access journals. It’s our privilege to recite you as a foremost strategist in the realm of research... Read More

New articles heading up for Volume 10 Pancreatic Disorders & Therapy

Image Pancreatic Disorders & Therapy is a peer reviewed medical journal that includes a wide range of topics in this field and creates a platform for the authors to contribute towards the journal. The editorial office promises to peer review the submitted manuscripts to ensure quality PDT is one of the best open access journal that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provides online access to the researchers worldwide without any... Read More

Instructions for authors for submissions: Pancreatic Disorders & Therapy

Image Pancreatic Disorders and Therapy is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Types of manuscripts accepted by the Journal includes Research, Short communication, Review, Mini Review, Case Report, Case Series,... Read More

About Transcriptomics technologies

Image Transcriptomics technologies are the techniques used to study an organism’s transcriptome, the sum of all of its RNA transcripts. The information content of an organism is recorded in the DNA of its genome and expressed through transcription. Here, mRNA serves as a transient intermediary molecule in the information network, whilst non-coding RNAs perform additional diverse functions. A transcriptome captures a snapshot in time of the total transcripts present in a cell. Transcriptomics technologies provide a broad account of which cellular processes are active and which are dormant. A major challenge in molecular biology lies in understanding how the same genome can give rise to different cell types and how gene... Read More

Primary Immunization among Children

Image Journal of Vaccines & Vaccination has completed 8 years of successful journey, now we are in 9th year for continuing the excellence in the publication field with the help of our glorious editors. We are accepting articles on the Human Vaccine Trials, Cancer Vaccines, Vaccine Adjuvants, Vaccine Preclinical vaccine studies, Childhood vaccines, HIV vaccines, Malaria vaccines, etc. Journal of Vaccines & Vaccination published an article titled: Primary Immunization among Children in Malaysia: Reasons for Incomplete which mainly focuses on immunization in Malaysia children. Incomplete primary immunization against vaccine-preventable diseases is a significant public health problem. This study... Read More

Lactococcosis in Reared Fish in Brazil and Control Strategies

Image Journal of Vaccines & Vaccination has completed 8 years of successful journey, now we are in 9th year for continuing the excellence in the publication field with the help of our glorious editors.  We are mainly focusing on publishing articles on the Human Vaccine Trials, Cancer Vaccines, Vaccine Adjuvants, Vaccine Preclinical vaccine studies, Childhood vaccines, HIV vaccines, Malaria vaccines, etc. Our journal accepting submission for the upcoming issue, authors can submit their works to us, which are research, review, short communication, case reports/studies, etc., which comes under the scope of our journal. Lactococcus garvieae is a Gram... Read More

Transcriptomics of Single Cell: New Discoveries to Become Basis for Future Studies

Image Single-cell transcriptome profiling has been an indispensable tool used for determining cell type, transcriptomic signatures, and single cell transcriptomics of ncRNAs. Нis technique could bring about a paradigm shiі in disease management and could even become the basis of further studies. to study the expression levels of mRNAs in a cell. Transcriptome, which is an umbrella term for all RNA molecules, play a vital role in studying human tissues at the cellular level, as it is a dynamic and good representative of the cellular state. Нis make it an indispensable tool to understand how... Read More

Journal of Biology and Today's World accomplished 8 Years Milestone in Research Publication Journey

Image Journal of Biology and Today's World  glad to invite eminent researchers to submit their valuable research for the final issue of Volume 8 in the year 2019. On-behalf of our editorial board we welcome original research, review, case reports, opinions, editorial, image articles, commentary articles covering a vast scope of Biology and Medicine. Journal of Biology and Today's World is a peer reviewed scientific journal known for rapid dissemination of high-quality research. Depression Journal with high impact factor offers an open access platform to the authors in academia and industry to publish their novel research. It serves the International... Read More

Join our Editorial Board - Journal of Biology and Today's World

Image Journal of Biology and Today's World (JBTW) is one of the best Open Access journals publishes the relevant and reliable information on the discoveries and current developments and all other areas of the field and making them freely available online without any restrictions or any other subscriptions to researchers worldwide. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of therapeutic techniques such as CytotoxicElectro, and the antimicrobial chemotherapies used to treat several dreadful diseases, particularly Cancer. It also accepts articles on immune suppressant and its application along with different aspects... Read More

Journal of Antivirals & Antiretrovirals Publication Ethics

Image Journal of Antivirals & Antiretrovirals provide the rapid publication of articles in all areas related to Antivirals & Antiretrovirals on quaterly basis. Journal of Antivirals & Antiretrovirals welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately one month after acceptance. This journal considers articles from all aspect of understanding related to Antivirals, Antiretrovirals, HIV, AIDS, Viral Immunity, Viral Vaccine, Bacteriophages, H1N1, Hepatitis, Interferons (IFNs), Antiretroviral Therapy, Viral Vectors, Cross Infection Control, Combination Therapy, Clinical Virology, Retrovirology, Emerging Viral Diseases, Protease Inhibitors, etc. As a member of Publisher International linking... Read More

Journal of Antivirals & Antiretrovirals Manuscript Submission

Image Journal of Antivirals & Antiretrovirals - Open Access using online manuscript submission, review and tracking systems of Longdom Publishing for quality and quick review processing. Longdom Publishing is using Online Review and Editorial Manager Systems for quality review process. Editorial Manager System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publication. E-mail is sent automatically to concerned persons when significant events occur. Submit your manuscript as an... Read More

Drug Designing: Open Access | Manuscript Submission

Image Journal of Drug Designing: Open Access is using online manuscript submission, review and tracking systems of Longdom Publishing SL for quality and quick review processing. Longdom Publishing SL is using Online Review and Editorial Tracking Systems for quality review process. Editorial Managerial System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publication. E-mail is sent automatically to concerned persons when significant events occur. Submit... Read More

Conference Announcement & Article Submission on Drug Discovery 2020

Image Co The perspective of the Drug Discovery Conference is to set up novel research techniques to help researchers understand how innovative techniques have advanced and how the field has developed in recent years. The pharmaceutical industry channels an important proportion of total research in most developed countries. In Europe, for example, it represents about 13% of total R&D. In recent years, pharmaceutical companies have been accused of devoting their resources mainly to minor improvements over existing medicines that require short clinical trials and have a small risk of not being accepted. The provision functions were an... Read More

New Issue Release 2020 -Journal of genetics syndrome and gene therapy[Upcoming Issue]

Image New Issue Release 2020 -Journal of genetics syndrome and gene therapy[Upcoming Issue] The Journal of genetics syndrome and gene therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics of genetics syndrome and gene therapy We are pleased to deliver the table of contents alert for Journal of genetics syndrome and gene therapy [ ISSN: 2157-7412].All the following articles are freely accessible in PDF and HTML formats. Readthrough Intervention Increases ER Stress in Wolfram Syndrome Wolfram syndrome (WFS) is an example of inherited... Read More

Genetic syndromes

Image Genetic syndromes Journal of Genetic Syndromes & Gene Therapy is an open access publisher which provides scientific information to all the researchers and academicians in all quarters. Journal of Genetic Syndromes & Gene Therapy (JGSGT) brings articles in all areas related to Genetics such as Genetic disorders, Genetic mutations, Auto immune diseases etc on Quaterly basis. JGSGT welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately 7 days after acceptance. https://www.longdom.org/genetic-syndromes-gene-therapy.html Relevant fields: 1.single-gene disorders include cystic fibrosis, alpha- and beta-thalassemias, sickle cell... Read More

Latest Published article-Journal of Astrobiology and Outreach

Image The Recent published article in the Journal of Astrobiology and Outreach was an Editor note “Our Fascination with Mars” written by Gary Boyle. Ancient mythology refers to it as the God of War. Tuesday, the second day of the week, is translated from the Latin ‘dies Martin’ and from French ‘mardi’. In fact the seven days of the week come from the five wandering planets, the Sun and Moon. It has been the love of science fiction writers and movie makers. Commonly known as the red planet, Mars has always had to extra bit... Read More

First Published Article: Journal of Astrobiology & Outreach

Image First Published Article: Journal of Astrobiology & Outreach   The very first published article in the Journal of Astrobiology and Outreach was an editorial entitled “Does Space Weather Matter to Astrobiology? The International Space Weather Initiative” written by Hans J Haubold Space weather events can have significant effects all the way from the Sun to Earth. They have been implicated in the depletion of ozone and cloud formation, and their signatures may even be seen in ice core records spanning more than 400 years into the past. Solar activity at other planets, and elsewhere... Read More

Primary Mixed Adenoneuroendocrine Carcinoma (MANEC) of Gallbladder

Image Primary Mixed Adenoneuroendocrine Carcinoma (MANEC) of Gallbladder Mixed adenoneuroendocrine carcinoma (MANEC), described and recognized by WHO in 2010, is a rare gastrointestinal neoplasm [1], characterized by the presence of at least 30% each of epithelial and neuroendocrine components [2]. Нe tumor may appear in various levels of the digestive tract including the oesophagus, stomach, colon and appendix, as well as other sites, such as the bladder. MANEC is an exceptionally rare neoplasm of gallbladder. Нe neoplasm occurs mostly in the middle-aged to elderly females with mean age of 64 years. Based on few case studies, suggested pathogenesis includes intestinal... Read More

Journal of Tumor Research: Chemotherapy for Stage II Classical Hodgkin Lymphoma

Image Journal of Tumor Research: Chemotherapy for Stage II Classical Hodgkin Lymphoma Journal of Tumor Research is an open access journal which covers different areas of all the tumors and cancer including breast cancer, prostrate, Lung cancer, ovarian cancer, malignant tumor cells, brain tissue, neurofibromatosis, multiple endocrine neoplasia, meningioma, neuroblastoma, astrocytoma and brain neoplasm. The most common type of tumors are glioblastoma and glioma. A metastatic tumours are the cancer cells that develop in a body organ such as the lung can spread via direct extension, or through the bloodstream to other body organs such as the brain. Other types of... Read More

Manuscript Submissions: Journal of Thyroid Disorders and Therapy

Image Manuscript Submissions: Journal of Thyroid Disorders and Therapy Journal of Thyroid Disorders and Therapy is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Manuscripts are subjected to rigorous peer review, where acclaimed scientists... Read More

Manuscript Submissions: Hair Therapy and Transplantation

Image Manuscript Submissions: Hair Therapy and Transplantation Hair Therapy and Transplantation is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  This top best scholarly journal is using Editorial Tracking System for quality in online manuscript... Read More

The mTOR Family of Proteins and the Regulation of Trophoblast Invasion by Gas6

Image Journal of Cell Signaling aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Computer Science and Information Technology. Abstract Objective: Preeclampsia is an obstetric complication wherein trophoblast invasion is decreased and high levels of serum Gas6 protein are present. Our objective was to assess members of the mTOR family that are plausibly involved in the invasion of trophoblast cells resulting from Gas6/AXL activation. Methods: Human first trimester cell line; (SW71), placental choriocarcinoma cell line (Jeg-3) and pulmonary alveolar type II-like cell line (A549) were treated... Read More

Cell activity and the signaling pathways

Image Cell signaling is a process through which living cells interact with the cellular environment and neighbouring cells. Cells contain Glycoproteins or Glycolipids as receptors on their plasma membrane which detects the signals. When a complementary ligand (signaling molecule) comes and binds to the receptor, it initiates a chain of reactions within the cell, ultimately leading to a response. Longdom Publishing SL organizes 1000+ conferences every year across USA, Europe & Asia with support from 1000 more scientific societies and publishes 700+ open access journals which contains over 50000 eminent personalities, reputed scientists as editorial board members. Journal of... Read More

SYPHILIS

Image SYPHILIS   Syphilis is a highly contagious disease that’s mostly spread through sexual activity, including oral and anal sex. The infected person often doesn’t know that they have the disease and passes it on to their sexual partner. Syphilis was once a major public health threat. It can cause serious long-term problems such as arthritis, brain damage, and blindness. There wasn’t an effective treatment until the late 1940s, when the antibiotic penicillin was developed. After the initial infection, the syphilis bacteria can remain inactive (dormant) in your body for decades before becoming active again. Early syphilis can be cured, sometimes... Read More

Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine Tumors with Mesenteric Tumor Deposits

Image Peritoneal Carcinomatosis in Well-Differentiated Small-Intestinal Neuroendocrine Tumors with Mesenteric Tumor Deposits Objective: Well-differentiated small-intestinal neuroendocrine tumors (SI-NETs) tend to be biologically indolent.Despite this tendency, they have a predilection for metastasis. Peritoneal involvement is quite common as isunfortunately peritoneal carcinomatosis (PC). PC is a dreaded metastatic complication due to the significant morbidity it creates for patients as well as well as increasing their mortality risk. The risk factors for PC development in SI-NETs remain understudied; however, one such factor may be the presence of mesenteric tumor deposits (MTDs). Methods: We performed a retrospective analysis on 208 well-differentiated SI-NET patient samples, the... Read More

Guillain-Barre Syndrome

Image Guillain-Barre syndrome (GBS) is an acute demyelinating inflammatory mediated polyneuropathy mediated by the immune system that leads to generalized flaccid paralysis. Most GBS cases are preceded by viral or bacterial infections of the respiratory or gastrointestinal tract, developing an aberrant response that causes autoantibody formation and complement and cytokine activation. Because it is a rare disease, diagnosis is often slow and may worsen the clinical picture. The patient should be evaluated by a multidisciplinary team and the treatment of choice is intravenous human immunoglobulin. We report a case in which the patient had several symptoms resulting from GBS, probably developed... Read More

Kidney Infection Diagnosis

Image Kidney Infection Diagnosis   Kidney infection, also known as renal infection or pyelonephritis, is a common type of urinary tract infection. Bacteria often infect the bladder or the urethra and spreads to one of the kidneys. Women are most commonly affected by kidney infection, as are pregnant mothers, children under 2 years of age, and individuals aged over 60 years. This article will explain the symptoms of a kidney infection and how it is diagnosed, prevented, and treated. Some key points about kidney infections: One of the kidney's major roles is to remove toxins from the body. Symptoms of... Read More

JOURNAL OF MOLECULAR IMAGING & DYNAMICS HEADING TOWARDS VOLUME 9

Image Who are we? The “Journal of Molecular Imaging & Dynamics” is a well-recognized journal with  ISSN: 2155-9937 With the successful publication of the eight volumes, the journal is moving towards its release of 9th volume which is a repository of molecular imaging, radio-pharmacology with focus towards the enables visualization of the cellular function and the follow-up of the molecular process in living organisms without perturbing. What do we accept? The journal invites the following: Research articles / Review articles Case Studie / Case Reports Editorials / Short Communications with major... Read More

Tranexamic Acid and Major Spine Surgery: Trends and Controversies

Image Excessive bleeding often complicates spine surgery. This may result in increased morbidity and mortality. The amount of blood loss depends on many factors. Нe extent of a surgical procedure is the principal cause of a blood loss during spine surgery. Perioperative coagulation dysfunction is also an important factor leading to an excessive blood loss during lengthy spinal surgeries. Tranexamic Acid (TA) is safely used for the prevention of blood transfusion for major joint replacement procedures. The benefit and safety of tranexamic TA in patients undergoing major spinal fusion is not completely established. Nevertheless, TA appears to have a potential role... Read More

Instructions for authors for submissions: Hair Therapy and Transplantation

Image Instructions for authors for submissions: Hair Therapy and Transplantation Hair Therapy and Transplantation is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Types of manuscripts accepted by the Journal includes Research, Short communication, Review,... Read More

Instructions for authors for submissions: Journal of Thyroid Disorders and Therapy

Image Instructions for authors for submissions: Journal of Thyroid Disorders and Therapy Journal of Thyroid Disorders and Therapy is an open access peer reviewed journal within the field of medical sciences which publishes the eminent research in all the fields of medical and health sciences.  Journal is having the Editorial Submission and Review Tracking System which provides the easy and feasible way to submit and track the manuscript by author and they can easily access about the review comments of their paper through this Editorial Submission and Review Tracking System.  Types of manuscripts accepted by the Journal... Read More

Journal of Surgery and Anesthesia Invites Editorial Board members

Image Journal of Surgery and Anesthesia is a peer reviewed, open access journal dedicated to publishing research on all aspects of surgery and anaesthesia. This journal aims to keep anaesthesiologists, anaesthetic practitioners, surgeons and surgical researchers up to date by publishing clinical & evidence based research. Journal of Surgery and Anesthesia addresses all aspects of surgery & anesthesia practice, including anesthetic administration, pharmacokinetics, preoperative and postoperative considerations, coexisting disease and other complicating factors, General Surgery, Robotic Surgery, Orthopedic Surgery, GI Surgery, Neurosurgery, Plastic Surgery, Cardiothoracic Surgery, Vascular Surgery, Urology, Surgical Oncology, Radiology, Ophthalmology, Pediatric Surgery, Trauma Services, Minimal Access Surgery, Endocrine... Read More

Applications & Challenges of Next Generation Sequencing

Image    Journal of Next Generation Sequencing & its Applications- NGSA (ISSN:2469-9853) aims to serve as a platform to young buddies in emerging and developing research areas in chemical sciences like DNA Sequencing, G protein–coupled receptor, mitosis-promoting factor, RNA processing, Whole genome sequencing, complementary DNA, Western blotting, microtubule-associated protein, allosteric transition, zinc finger, autonomously replicating sequence and to link with centers of excellence worldwide to provide authoritative coverage and references in focused and specialist fields. The Journal of Next Generation Sequencing & its Applications aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all... Read More

Scientific Survey on Drugs and its Metabolites

Image Journal of Developing Drugs is an open access Scientific Journal which mainly focuses on articles of Drug designing. The Journal of Developing Drugs comes up with an opportunity to researchers and scientist to explore advance research in Drug Development. The Journal of Developing Drugs is of highest standards in terms of quality.   The editorial team of Developing Drugs and Research is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal. During this year we look forward to taking some initiates that would encourage and reward our prospective customers.... Read More

Theoretical and Computational Science: A Better Way to Modern Science

Image On behalf of the Journal, as Editor-in-Chief, it is my distinct honour and privilege to welcome you to the Journal of Theoretical and Computational Science. The Journal of Theoretical and Computational Science aims to spread knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Modern Scientific Techniques. The open access journal is published by Longdom Publishing who hosts open access peer-reviewed journals as well as organizes conferences that hosts the work of researchers in a manner that exemplifies the highest standards in research integrity. We are delighted to... Read More

Immunotherapy: Open access wants to thank the eminent researchers

Image On the occasion of entering into its 5th anniversary Immunotherapy: Open access wants to thank the most cited research in the journal.   The article entitled “Joint Action of the Nano-sized System of Small Non-coding RNAs with DDMCVector and Recombinant IL-7 Reprograms A-549 Lung Adenocarcinoma Cellsinto CD4+ Cells” by the researcher Oxana V. Klimenko from SID ALEX GROUP, Ltd. Kyselova 1185/2, Prague, Czech Republic.   The abstract of the article is as follows: Small non-coding RNAs, as class of small regulatory molecules, control normal development and differentiation ofcells. ... Read More

Journal of Astrobiology & Outreach-A view of Special Issue

Image Journal of Astrobiology & Outreach-A view of Special Issue Astrobiology is the study of life in the universe. The search for life beyond the Earth requires an understanding of life, and the nature of the environments that support it, as well as planetary, planetary system and stellar processes. To provide this understanding, astrobiology combines the knowledge and techniques from many fields, including astronomy, biology, chemistry, geology, atmospheric science, oceanography and aeronautical engineering. Journal of Astrobiology & Outreach seeks innovative proposals to create special issues related to research works in environmental and allied sciences. Through special issues addressed to specific challenges... Read More

Current research on Genetic Syndrome and Gene Therapy

Image Current research on Genetic Syndrome and Gene Therapy The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. On behalf of the Journal of Genetic Syndromes & Gene Therapy, as Editor-in-Chief, it is my great pleasure and honour to welcome you to the Journal of Genetic Syndromes & Gene Therapy. Natural Compounds as Therapeutic Agents in the Treatment Cystic Fibrosis The recent FDA approval of two drugs to treat the basic defect in cystic fibrosis has given... Read More

Use of genomics to balance cure and complications

Image Use of genomics to balance cure and complications The Journal of Genetic Syndromes & Gene Therapy aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to genetics. The open access journal is published by longdom who hosts around 350 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences. Journal of Genetic Syndromes & Gene Therapy (JGSGT) brings articles in all areas related to Genetics such as Genetic disorders, Genetic mutations, Auto immune diseases etc on Quaterly basis. JGSGT welcomes the submission... Read More

All about Probiotics

Image Probiotics are microorganisms naturally present in the digestive tract that aid in digestion and reduce inflammation. The normal human digestive tract contains about several types of probiotic bacteria that reduce the growth of harmful bacteria and promote a healthy digestive system. The largest group of probiotic bacteria in the intestine is lactic acid bacteria, of which Lactobacillus acidophilus is the best known. A healthy digestive system is vital to good health. The food that you eat is processed and the nutrients you consume are absorbed in the digestive system. Probiotic supplements... Read More

Journal of Tumor Research: Manuscipt submission.

Image Journal of Tumor Research: Manuscipt submission. Journal of Tumor Research - Open Access using online manuscript submission, review and tracking systems of Longdom Publishing SL for quality and quick review processing. Longdom Publishing SL is using Online Review and Editorial Tracking Systems for quality review process. Editorial Managerial System is an online submission and review system, where authors can submit manuscripts and track their progress. Reviewers can download manuscripts and submit their opinions. Editors can manage the whole submission/review/revise/publish process. Publishers can see what manuscripts are in the pipeline awaiting publication. E-mail is sent automatically to concerned persons when significant... Read More

Isolated Bronchial Injury A Diagnostic and Management Challenge

Image The injuries of major airways in high speed motor vehicle accidents is a relatively uncommon with a reported incidence of 0.03%-3%.Besides blunt chest injuries, the presence of associated other multiple injuries (head, facial, spine, abdomen, vascular and orthopaedic) are important determinants of outcome. In 25% of cases, deaths are due to thoracic trauma. The airway injury is mostly fatal and it is reported that a large proportion (81%) of the airway injury patients died immediately or before reaching the hospital due to tension pneumothorax. The incidence of trachea-bronchial tree injury is0.5% in blunt trauma and 1-2% in penetrating trauma. Isolated... Read More

Journal of Tumor Research: Special Issue

Image Journal of Tumor Research: Special Issue Special Issue Guidelines (Clinical) Longdom Publishing SL welcomes proposals for creating special issues that fall within the scope of the Journal of Tumor Research published by Longdom Publishing SL. The special issue aims at exploring new, relevant, and most compelling dimensions in the field of Tumor Research and its therapy that missed a mention in the journal on a regular basis. Proposal Preparation Special issues will be released on a monthly basis and proposals will be accepted accordingly. All proposals should include the following information: Title of the proposed special issue Purpose and current... Read More

Applied Microbiology: Open Access –Invite to Reviewers

Image Applied Microbiology: Open Access –Invite to Reviewers   Applied Microbiology: Open Access (Longdom Publishing S.L) has announced almost 50 percent discount on article processing charge. It is a great honor and pleasure for me to invite you to participate in this themed issue by contributing your unique idea for our forthcoming issues (volume5, issue3) in the form of research/review/case report/short communication/commentaries to our journal and providing hefty discount of up to 50 percent on one-time article processing charge.   Journal of Applied Microbiology (AMOA) is an open access, peer-reviewed journal that focuses on all... Read More

Applied Microbiology: Open Access-an overview

Image Applied Microbiology: Open Access-an overview Applied Microbiology is a peer-reviewed Open Access Journal, encourages on-going international research and articles related to but not limited to Medical microbiology, pathogenic microbes, Pharmaceutical microbiology (antibiotics, enzymes, vitamins, vaccines) Industrial microbiology, Microbial biotechnology, Plant pathology, Veterinary, Food, Agricultural, Soil, Environmental Microbiology, etc. Applied Microbiology: Open Access follows Editorial Tracking System for quality in peer review process. Editorial Tracking is an online manuscript submission, review and tracking systems used by most of the best open access journals. The Journal Applied Microbiology: Open Access accepts articles in the form of research articles, review... Read More

4th Anniversary: Journal of Food: Microbiology, Safety & Hygiene

Image On behalf of the Journal of Food: Microbiology, Safety & Hygiene , as Editor, it is my distinct honour and privilege to inform you that, it’s been four long years we have started the Journal, now we are celebrating the 4th Anniversary and we are privileged to welcome researchers to our journal. As Editor it is my great pleasure and honour to welcome you to the Journal of Food: Microbiology, Safety & Hygiene. The Journal of Food: Microbiology, Safety & Hygiene aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers... Read More

MOLECULAR IMAGING & DYNAMICS REACHES A NEW MILESTONE

Image The team “Journal of Molecular Imaging & Dynamics”, Welcomes you to the most accessed “open access publication – Longdom Publishing” page with 25+ Million reader base.Journal of Molecular Imaging & Dynamics” progresses forward reviewing and disseminating the recent advances in molecular imaging, radio-pharmacology with focus towards the enables visualization of the cellular function and the follow-up of the molecular process in living organisms without perturbing. Longdom Publishing hosts around 215 open access peer-reviewed journals as well as organizes more than 100 International... Read More

Instructions for Authors Regarding Article Submission- Transcriptomics: Open Access

Image Transcriptomics: Open Access (TOA) provides the Half-Yearly publication of articles in all areas related to medical science like Transcripotme,TOA welcomes the submission of manuscripts that meet the general criteria of significance and scientific excellence. Papers will be published approximately one month after acceptance. Submit as an e-mail attachment to the Editorial Office at editor.toa@jpeerreview.com A manuscript number will be e-mailed to the corresponding author within 72 hours. Article Processing Charges: Transcriptomics: Open Access is organized by Longdom Publishing, a self supporting organization and does not receive funding from any institution/government. Hence, the operation of the Journal... Read More

Future Visualizing in Artificial Intelligence

Image AI & Swarm intelligence is the latest trending technology in many fields especially in industries like Manufacturing, Automation, Control Systems, Healthcare, Energy, Transport, Defence, Space, Data Mining, etc. Artificial Intelligence will be a common platform to gain knowledge and share new ideas amongst the Technologist, Professionals, Industrialists, Researchers, Innovators and students from research area of Machine Learning. Experts will share their research experiences and engage in many interactive discussions at the event. Our high-level conferences will bring together forward thinking brands, market leaders, AI & Swarm intelligence evangelists... Read More

Visualizing the Latest Technologies in Swarm Intelligence

Image Machine Learning and Computational Intelligence There is an increasing need for the application of Machine Learning (ML) and Computational Intelligence (CI) techniques, which can effectively perform image processing operations (such as segmentation, co-registration, classification, and dimensionality reduction), in the fields of neuroimaging and oncological imaging. Although the manual approach often remains the golden standard in some tasks (e.g., segmentation), ML can be exploited to automate and facilitate the work of researchers and clinicians. Frequently used techniques include Support Vector Machines (SVMs) for classification problems, graph-based methods, and Artificial Neural Networks (ANNs).... Read More

Present Innovations in Ophthalmic Surgery for the Treatment of Eye Diseases

Image "Ophthalmic Surgery” gathering will focus on most recent and energizing developments in zones of eye medical procedures, diagnostics and late advances towards eye mind. Since the eventual fate of ophthalmology lies in research, information and innovation and its quick interpretation into the center to encourage patients 2019" is the latest slanting development in numerous fields especially in wanders like remedial, restorative fields, affiliations, associations et cetera. The present time totally taken off with various new computerization developments . In such case recuperating focuses and distinctive organizations are exceptionally benefitted by the use of ... Read More

Exploring current trends & future innovations in Ophthalmology

Image Acanthamoeba Keratitis Acanthamoeba Keratitis this is an unseen disease which the amoeba can occur at the corner of the eye which results in the permanent loss of visual on eyes.  It’s mostly can cause with the contact lenses. They should be properly disinfected before we wear them. While swimming or in cases of surfing it should be removed. There are many cases regarding Acanthamoeba, who don’t wear contact lenses. This disease can cause by a free-living amoeba it’s called a single-celled living organism. They can find in soil, dust, water sources. It can often... Read More

Scope of Drug Designing: Open Access Journal

Image   Scope of Drug Designing: Open Access Journal   Drug Designing: Open Access is an international peer reviewed open access journal presenting original research and contributions and scientific advances in the field of drug design and development. Drug Designing  journal welcomes research articles, review articles, letter to the editors, editorials, case reports and innovations relating to all aspects of drug design and development and related sciences.  Drug Designing Journal is a cutting edge, and platform for authors to make their contribution. It focuses on the latest research in all related fields of drug targets, rational drug discovery, computer-aided... Read More