Latest Breakthrough in Cell signaling
Journal of Cell Signaling brings articles in all areas related to effector systems, such as protein kinases, lipid signaling pathways, cyclic nucleotide signaling processes, NO signaling and ion channels. The production, regulation, degradation and action of second messengers; the structure, regulation, degradation and action of receptors; Guanine nucleotide regulatory proteins; Bio-informatics studies related to cell signaling mechanisms. A new area for bioscience and clinical researchers to explore.
In humans, signalling in cells normally regulates cell growth and repair. However, abnormal cell signalling contributes to many diseases, including cancer and neurodegeneration. Therefore, identifying specific proteins that control cell signalling in healthy and disease states could help accelerate the discovery of disease biomarkers and drug targets.Protein phosphorylation, which involves the addition of phosphate groups to proteins, is a key regulator of protein function, and defining site-specific phosphorylation is essential to understand basic and disease biology. In vertebrates, research has primarily focused on phosphorylation of the amino acids serine, threonine and tyrosine. However, mounting evidence suggests that phosphorylation of other 'non-canonical' amino acids also regulates critical aspects of cell biology.
Unfortunately, standard methods of characterisation of protein phosphorylation are largely unsuitable for the analysis of these novel types of non-canonical phosphorylation. Consequently, the complete landscape of human protein phosphorylation has, until now, remained unexplored.This study reports on a new phosphopeptide enrichment strategy, which permits identification of histidine, arginine, lysine, aspartate, glutamate and cysteine phosphorylation sites on human proteins by mass spectrometry-based phosphoproteomics.
Remarkably, the researchers found that the number of unique 'non-canonical' phosphorylation sites is approximately one-third of the number of sites of phosphorylation observed on the more well-studied serine, threonine and tyrosine residues.
It gives us great pleasure to announce the call for paper on the occasion of 04th Anniversary of the Journal .The Journal of Cell Signaling accepts all types of articles including research, review, case reports, commentaries, hypotheses, meeting reports and short reports. This scientific journal is using Editorial Tracking System for maintaining quality in peer review process. Review processing is performed by the editorial board members of Journal of Cell signaling or by outside experts. Minimum two independent reviewers approval followed by editor approval is mandatory for acceptance of any manuscript. Manuscripts can be uploaded online at Editorial Tracking System (https://www.longdom.org/submissions/cell-signaling.html) or forwarded to the Editorial Office firstname.lastname@example.org, email@example.com
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Journal of Cell Signaling