The team “Drug Designing: Open Access”, welcomes you to the most accessed “open access publication – Longdom Publishing” page with 25+ Million reader base.

The Journal of Drug Designing: Open Access progresses forward reviewing and disseminating the recent advances in pharmaceutical industry with focus towards the drug discovery, drug design by rational approach. Longdom Publishing hosts around 215 open access peer-reviewed journals as well as organizes more than 100 International scientific Conferences.

The Journal of Drug Designing: Open Access is a peer-reviewed journal accepting research papers on topics related to drug discovery, drug design by rational approach, target-based design, drug synthesis, drug metabolism, structure-based drug design, molecular modeling, ligand-based interaction, development of the generic drug, in silico chemoinformatics and bioinformatics technologies, receptor agonist/antagonist, protease substrate/inhibitor, peptidomimetic, Quality by design, Design for reliability in drug development, Design for traditional Chinese medicine clinical trials, Bayesian sequential design for multi-regional design, Design and analysis for target clinical trials, Design and analysis for diagnostic procedures, Adaptive design for early clinical development, Design for biosimilar studies, Design for bioassay development and validation, Design for statistical genetics, Design for assessment of drug to drug interaction, Design for bridging studies, Design for stability analysis.

Highlights

• All populations of living organisms show heterogeneity among their individual cells.
• Strategies for characterization of the metabolome of single cells are continually evolving
• Current technologies allow detection of hundreds of metabolites from a single cell
• Sample preparation remains a significant challenge in single cell metabolomics
• Studies of metabolomics promise to provide a greater understanding of cellular fate, function, and homeostatic balance

Metabolomics is one omics approach that can be used to acquire comprehensive information on the composition of a metabolite pool to provide a functional screen of the cellular state. Single-cell metabolomics is proving useful at the molecular level for major biological research in drug development. One of the main goals of single-cell metabolomics research is to gain knowledge of cellular interaction with and in response to environmental influences on a molecular level, through a comprehensive understanding of cellular functions. In this short review, we discuss the importance of single-cell metabolomics, the concentrations of metabolites in cells, single-cell isolation, analytical methodologies for single-cell metabolomics, future prospects and a possible strategy for studying single-cell metabolomics by combining Fluorescence-activated cell sorting (FACS), Cytometry by time-of-flight (CyTOF) and Liquid Chromatography with tandem mass spectrometry (LC-MS/MS).

The journal publishes the articles under open access policy with creative commons attribution license [CC-BY-NC 4.0] permitting third party reuse with appropriate citation in addition to the retention of content copyright by the author.

In addition to archiving, the published articles are also promoted through various scientific and social media as well as through International indexation and abstracting services.

Regards,
Sherry Peterson
Journal Manager
Journal of Drug Designing: Open Access
drugdesign@longdom.org
 WhatsApp: +1-947-333-4405