CRISPR gene cuts may offer new way to chart human genome


Author Name: Keith Howell

Category Name: Genetics and molecular Biology

Description: CRISPR gene cuts may offer new way to chart human genome.

On behalf of the  Journal of  Cell Signaling , as Editor-in-Chief, it is my distinct honour and privilege to inform you that, it’s been four years we have started the Journal, now we are celebrating the 4th Anniversary and we are privileged to welcome cell biologist to our journal. It gives us great pleasure to announce the call for paper on the occasion of 04th Anniversary of the Journal

In search of new ways to sequence human genomes and read critical alterations in DNA, researchers say they have successfully used the gene cutting tool CRISPR to make cuts in DNA around lengthy tumour genes, which can be used to collect sequence information.

The researchers say that pairing CRISPR with tools that sequence the DNA components of human cancer tissue is a technique that could, one day, enable fast, relatively cheap sequencing of patients' tumours, streamlining the selection and use of treatments that target highly specific and personal genetic alterations.

For tumour sequencing in cancer patients, you don't necessarily need to sequence the whole cancer genome," says researcher. "Deep sequencing of particular areas of genetic interest can be very informative. In conventional genome sequencing, scientists have to make many copies of the DNA at issue, randomly break the DNA into segments, and feed the broken segments through a computerized machine that reads the string of chemical compounds called nucleic acids, made up of the four "bases" that form DNA, and are lettered A, C, G and T. Then, scientists look for overlapping regions of the broken segments and fit them together like tiles on a roof to form long regions of DNA that make up a gene.

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