Commentary on “Association of mir12475p Expression with Clinicopathological Parameters and Prognosis in Breast Cancer


Commentary on Association of mir12475p Expression with Clinicopathological Parameters and Prognosis in Breast Cancer

Breast cancer is the most common form of cancer and the second most common cause of cancer death in women. Although great advances have been made in clinical treatments, satisfactory outcomes have not always been achieved. Нus prevention and treatment of breast cancer still remains a concern and challenge for oncologists throughout the world. Early detection is one of the most important methods which might improve the survival of breast cancer patients, so it remains sLJnLٽcDnt to ٽnd new biomarkers for diagnosis and prognosis estimation of breast cancer. Cancer initiation and progression can involve microRNAs (miRNA), which are small noncoding RNAs that can regulate gene expression. More and more studies showed that microRNAs could be promising biomarkers for diagnosis, prediction of therapy response and prognosis of breast cancer. As I know, it was the ٽrst paper in which the relationship of mir-1247-5p and breast cancer has been investigated. According to our study, mir-1247-5p could be a novel tumor suppressor and its lower expression was associated with malignant biological behavior and poor prognosis of breast cancer. In latest study, mir-1247-5p was down-regulated in breast cancer and this is in accordance with our conclusion. Although it was a pity that we could not complete the functional assay in this study, we mentioned a variety of pathways which mir-1247-5p might be involved in section of discussion. I want to say that mir-1247-5p may not be a common suppressor as other one`

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