Cardiovascular diseases

Cardiovascular diseases (CVD’s) remain one of the major reasons ofmortality universally, although since last two decades cardiovasculardeath rates have reduced in several developed countries. CVD are aninternational cause of death and accounts up to 31% of deaths alone, inIndia. They are the foremost reason for morbidity and mortalitytogether in rural and urban India. The burden of CVD and its hazardfactors in India makes it intended for a sound public healthadvancement to eradicate the epidemic. One such cardiovascularanarchy is Cardiomyopathy, which is a heterogeneous group ofdiseases linked with myocardial dysfunction and exhibiting improperventricular hypertrophy or dilatation owing to an array of causeswhich are generally genetic. The changes in the environmental,hereditary conditions and mostly the innate immune responsealterations play a significant role in pathogenesis of cardiomyopathy. It have been hypothesized that the immune response is not steadyall through the population and diverse motifs of immune response aremeasured to be associated through the polymorphisms in the immunegenes. Distorted expression of innate immunity genes causes anunevenness in pro- and anti-inflammatory cytokines, which has beeninvolved in the development and unremitted course of cardiacdysfunction. The cytokine macrophage migration inhibitoryfactor (MIF), CD14, and Toll-like receptor 4 (TLR4) are interlinkedcomponents through evidently definite roles in immunologic andinflammatory pathways.

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Alex john
Editorial assistant
Immunotherapy Open Accress